Abstract

Diet is an environmental factor in autoimmune disorders, where the immune system erroneously destroys one’s own tissues. Yet, interactions between diet and autoimmunity remain largely unexplored, particularly the impact of immunogenetics, one’s human leukocyte antigen (HLA) allele make-up, in this interplay. Here, we interrogated animals and plants for the presence of epitopes implicated in human autoimmune diseases. We mapped autoimmune epitope distribution across organisms and determined their tissue expression pattern. Interestingly, diet-derived epitopes implicated in a disease were more likely to bind to HLA alleles associated with that disease than to protective alleles, with visible differences between organisms with similar autoimmune epitope content. We then analyzed an individual’s HLA haplotype, generating a personalized heatmap of potential dietary autoimmune triggers. Our work uncovered differences in autoimmunogenic potential across food sources and revealed differential binding of diet-derived epitopes to autoimmune disease-associated HLA alleles, shedding light on the impact of diet on autoimmunity.

中文翻译：

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Immunodietica：询问饮食在自身免疫性疾病中的作用。

摘要

饮食是自身免疫性疾病的环境因素，其中免疫系统错误地破坏了自己的组织。然而，饮食和自身免疫之间的相互作用在很大程度上仍未得到探索，尤其是免疫遗传学，即人类白细胞抗原 (HLA) 等位基因构成在这种相互作用中的影响。在这里，我们询问了动物和植物是否存在与人类自身免疫疾病有关的表位。我们绘制了跨生物体的自身免疫表位分布图，并确定了它们的组织表达模式。有趣的是，与保护性等位基因相比，与疾病相关的饮食来源的表位更有可能与与该疾病相关的 HLA 等位基因结合，具有相似自身免疫表位含量的生物体之间存在明显差异。然后我们分析了一个人的 HLA 单倍型，生成潜在饮食自身免疫触发的个性化热图。我们的工作揭示了不同食物来源自身免疫原性潜力的差异，并揭示了饮食衍生表位与自身免疫性疾病相关 HLA 等位基因的不同结合，揭示了饮食对自身免疫的影响。