ABSTRACT

Aim

Patients with autoimmune connective tissue disease (ACTD) may have anti-thyroid peroxidase antibody (TPOAb) and anti-thyroglobulin antibody (TgAb). This study aimed to compare the prevalence of thyroid autoantibodies in ACTD patients and controls.

Methods

All case-control studies published between 1980 and 2019 in English were searched from Medline, Embase, Web of Science, PubMed databases for meta-analysis and subgroup analyses.

Results

Total 10,321 ACTD cases and 12,949 healthy controls were included, and the prevalence of thyroid autoantibody positivity was higher in ACTD patients than in controls. Subgroup analysis revealed positive association between TgAb and ACTD in populations from all continents including European, Asian, African, and American. In addition, we found positive association between TgAb positivity and most ACTD cases including RA, SLE, pSS, and UCTD, positive association between TPOAb positivity and all ACTD cases including RA, SLE, pSS, SSc, and UCTD, and positive association between TPOAb positivity and ACTD in European, Asian, and African but not in American populations.

Conclusion

Thyroid autoantibodies are more prevalent in ACTD patients than in healthy controls. It is important to screen patients with ACTD for the presence of thyroid autoimmunity, and perform thyroid function tests in clinical evaluation of ACTD patients.

中文翻译：

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甲状腺自身抗体在自身免疫性结缔组织疾病中的患病率：系统评价和荟萃分析。

摘要

目的

自身免疫性结缔组织病 (ACTD) 患者可能有抗甲状腺过氧化物酶抗体 (TPOAb) 和抗甲状腺球蛋白抗体 (TgAb)。本研究旨在比较 ACTD 患者和对照组甲状腺自身抗体的患病率。

方法

从 Medline、Embase、Web of Science、PubMed 数据库中检索了 1980 年至 2019 年间以英文发表的所有病例对照研究，以进行荟萃分析和亚组分析。

结果

共纳入10321例ACTD病例和12949例健康对照，ACTD患者甲状腺自身抗体阳性率高于对照组。亚组分析显示，在来自欧洲、亚洲、非洲和美洲等各大洲的人群中，TgAb 和 ACTD 呈正相关。此外，我们发现 TgAb 阳性与大多数 ACTD 病例（包括 RA、SLE、pSS 和 UCTD）呈正相关，TPOAb 阳性与所有 ACTD 病例（包括 RA、SLE、pSS、SSc 和 UCTD）呈正相关，TPOAb 与所有 ACTD 病例呈正相关阳性和 ACTD 在欧洲、亚洲和非洲，但在美国人群中没有。

结论

与健康对照组相比，ACTD 患者的甲状腺自身抗体更为普遍。筛查 ACTD 患者是否存在甲状腺自身免疫，并在 ACTD 患者的临床评估中进行甲状腺功能检查非常重要。