Abstract Biofilms were grown on smooth acrylic surfaces for nominal incubation times of three, five, and ten weeks in a flow loop at the University of Michigan. The biofilm covered surfaces were exposed to the turbulent flow in a high-aspect ratio, fully developed channel flow facility at height-based Reynolds numbers from ReH ≈ 5,000 to 30,000. Measurements of the pressure drop along each fouled upper surface revealed that the friction drag increased from approximately 10% to 400%. The wide range in drag penalty was linked to variations in flow speed, the average thickness of the biofilms, and the level of film coverage over each surface through scaling parameters and empirical correlations. Rigid replicas of select biofilms were produced from time-averaged laser scans collected while the biofilm was subjected to flow. These rigid biofilm replicas experienced roughly half the drag increase of their compliant counterparts with the increase in friction spanning roughly 50% to 200%.

中文翻译：

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丝状生物膜的药物产生机制

摘要 在密歇根大学的流动回路中，生物膜在光滑的丙烯酸表面上生长，标称孵育时间为 3、5 和 10 周。生物膜覆盖的表面暴露于高纵横比的湍流中，完全发达的通道流动设施在基于高度的雷诺数从 ReH ≈ 5,000 到 30,000。沿每个脏污的上表面的压降测量表明，摩擦阻力从大约 10% 增加到 400%。阻力损失的广泛范围与流速的变化、生物膜的平均厚度以及通过缩放参数和经验相关性在每个表面上的膜覆​​盖水平有关。选择生物膜的刚性复制品是通过在生物膜流动时收集的时间平均激光扫描产生的。