This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily of transporter proteins and their roles in human cells. The SLC superfamily currently includes 458 transport proteins in 65 families that carry a wide variety of substances across cellular membranes. While members of this superfamily are found throughout cellular organelles, this review focuses on transporters expressed at the plasma membrane. At the cell surface, SLC proteins may be viewed as gatekeepers of the cellular milieu, dynamically responding to different metabolic states. With altered metabolism being one of the hallmarks of cancer, we also briefly review the roles that surface SLC proteins play in the development and progression of cancer through their influence on regulating metabolism and environmental conditions.

中文翻译：

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质膜溶质载体蛋白指南

本综述旨在介绍转运蛋白的溶质载体蛋白 (SLC) 超家族及其在人类细胞中的作用。SLC 超家族目前包括 65 个家族的 458 个转运蛋白，可跨细胞膜携带多种物质。虽然这个超家族的成员遍布于整个细胞器中，但本综述重点关注在质膜上表达的转运蛋白。在细胞表面，SLC 蛋白可被视为细胞环境的看门人，动态响应不同的代谢状态。由于代谢改变是癌症的标志之一，我们还简要回顾了表面 SLC 蛋白通过影响调节代谢和环境条件在癌症发生和进展中所发挥的作用。