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Periodontitis and diabetes reshape neuronal dendritic arborization in the thalamus and nucleus oralis in the rat
SYNAPSE ( IF 2.3 ) Pub Date : 2020-08-18 , DOI: 10.1002/syn.22187
Julia Flores-Tochihuitl 1 , Beatriz Márquez Villegas 1 , Anahí Catalina Peral Lemus 2 , Cristian Jesús Andraca Hernández 1 , Gonzalo Flores 3 , Julio César Morales-Medina 4
Affiliation  

Diabetes is a metabolic disorder resulting in long‐term hyperglycemia that could induce oxidative stress as well as neural modifications in the central nervous system. Periodontal disease is highly comorbid with diabetes and in some cases, with exacerbated pain responses. Periodontal tissue is innervated by trigeminal afferents which extend to the nucleus oralis (NO) that sends input to the ventral posterior lateral thalamic nuclei (VPL). The present study aimed to evaluate the consequences of periodontitis, diabetes and both conditions on the dendritic morphology, spine type, and density in neurons of the NO and VPL in male and female rats. A quantitative neuromorphological analysis was performed using the Cox‐Golgi staining in male and female rats in four groups: naïve control, after a periodontitis procedure, diabetic, and diabetic with periodontitis. Periodontitis decreased the total dendritic length (TDL) in the NO of the male rat but no change in the female rat and no neuronal alterations were observed in the VPL of both male and female rats. In contrast, diabetes increased the number of spines in the NO and VPL and decreased TDL in the NO in both male and female rats. We observed that periodontitis induced a dimorphic effect in the NO, whereas diabetes induced a strong neuromorphological effect regardless of sex. Moreover, while periodontitis had a limited effect on the neuronal morphology, it dramatically modified the neural consequences in the VPL and NO when comorbid with diabetes. In conclusion, these neuroplastic modifications may be relevant to understand how diabetes exacerbates the outcome of periodontitis in humans, particularly in the female population.

中文翻译:

牙周炎和糖尿病重塑大鼠丘脑和口核神经元树突状树枝状结构

糖尿病是一种代谢紊乱,导致长期高血糖,可诱发氧化应激以及中枢神经系统的神经改变。牙周病与糖尿病高度合并,在某些情况下,疼痛反应加剧。牙周组织由延伸到口核 (NO) 的三叉神经传入神经支配,口核将输入发送到腹侧丘脑后外侧核 (VPL)。本研究旨在评估牙周炎、糖尿病和这两种疾病对雄性和雌性大鼠 NO 和 VPL 神经元树突形态、脊柱类型和密度的影响。使用 Cox-Golgi 染色对四组雄性和雌性大鼠进行定量神经形态学分析:幼稚对照组、牙周炎手术后、糖尿病组、和患有牙周炎的糖尿病患者。牙周炎减少了雄性大鼠 NO 的总树突长度 (TDL),但雌性大鼠没有变化,雄性和雌性大鼠的 VPL 均未观察到神经元改变。相反,糖尿病增加了雄性和雌性大鼠 NO 和 VPL 中刺的数量,并降低了 NO 中的 TDL。我们观察到牙周炎在 NO 中诱导了二态效应,而糖尿病诱导了强烈的神经形态学效应,而与性别无关。此外,虽然牙周炎对神经元形态的影响有限,但当与糖尿病共存时,它显着改变了 VPL 和 NO 的神经后果。总之,这些神经可塑性改变可能与了解糖尿病如何加剧人类牙周炎的结果有关,
更新日期:2020-08-18
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