Pythium root rot (PRR) caused by Pythium spp. is an important root rot disease affecting common bean productivity. The objective of this study was to conduct a genome‐wide association analysis of resistance to PRR in the common bean of Andean gene pool using single nucleotide polymorphism (SNP) markers. About 260 genotypes of the Andean diversity panel (ADP) were evaluated under screen house conditions using Pythium ultimum isolate MS61 in Uganda. Sixteen significant signals for resistance to PRR were detected on chromosomes Pv01, Pv02, Pv04, Pv05 and Pv09 using 260K GBS‐based and 6K Beadchip SNPs. Common significant signals were detected on Pv02 and Pv09 for PRR. Positional candidate genes associated with significant SNPs on Pv02 were Phvul.002G119700, 16.97 kb near marker S02_25507837 (25.50 Mb), encoding Subtilase family protein, and Phvul.002G278400 near marker ss715645959 (44.79 Mb) encoding Defensin‐like (DEFL) protein involved in plant defence responses. Based on the relatively high heritability estimates observed for PRR in this study, significant SNP markers associated with genomic regions for resistance to PRR could be validated for marker‐assisted breeding in Andean beans.

中文翻译：

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普通豆（菜豆）对终极腐霉的抗性的全基因组关联分析

由腐霉属引起的腐霉根腐病（PRR）。是影响普通豆生产力的重要根腐病。这项研究的目的是使用单核苷酸多态性（SNP）标记对安第斯山脉普通豆中的PRR抗性进行全基因组关联分析。在乌干达，使用终极腐霉菌分离株MS61在筛选房条件下评估了约260个基因型安第斯多样性小组（ADP）。使用基于260K GBS和6K Beadchip SNP的Pv01，Pv02，Pv04，Pv05和Pv09染色体检测到16种抗PRR的重要信号。在Pv02和Pv09上检测到PRR共同的重要信号。与Pv02上的重要SNP相关的位置候选基因为Phvul.002G119700附近标志物S02_25507837（25.50 MB），编码枯草杆菌蛋白酶家族蛋白，和16.97 KB Phvul.002G278400靠近标记ss715645959（44.79 MB）编码防御样参与植物的防御反应（DEFL）蛋白。基于本研究中观察到的相对较高的PRR遗传力估计值，可以验证与PRR抗性的基因组区域相关的重要SNP标记可用于安第斯豆的标记辅助育种。