Autophagy is a major catabolic pathway that must be tightly regulated to maintain cellular homeostasis. Protein intrinsic disorder provides a very suitable conformation for regulation; accordingly, the molecular machinery of autophagy is significantly enriched in intrinsically disordered proteins and protein regions (IDPs/IDPRs). Despite experimental challenges that the characterization of IDPRs encounters, remarkable progress has been made in recent years in revealing various roles of IDPs/IDPRs in autophagy. This chapter describes the autophagy pathway from a specific point of view, that of IDPRs. It focuses in detail on structural and mechanistic functions in autophagy that are executed by disordered regions. Via a description of autophagosome biogenesis, linking the cargo to the autophagy machinery, as well as a discussion of certain post-translational regulations, this review reveals many indispensable roles of IDPRs in the functional autophagy pathway. Devastating pathologies such as neurodegeneration, cancer, or diabetes have been linked to a malfunction in IDPs/IDPRs. The same pathologies are associated with dysfunctional autophagy, indicating that autophagic IDPRs may be a paramount causative factor. Several disease-related mechanisms of the autophagy pathway involving protein intrinsic disorder are reported in this chapter, to illustrate a wide-ranging potential of IDPRs in the therapeutic modulation of autophagy.

自噬是主要的分解代谢途径，必须严格调节以维持细胞稳态。蛋白质内在障碍为调节提供了非常合适的构象。因此，自噬的分子机制在本质上无序的蛋白质和蛋白质区域（IDP / IDPR）中明显丰富。尽管鉴定IDPR遇到了实验挑战，但近年来在揭示IDP / IDPR在自噬中的各种作用方面取得了显着进展。本章从特定角度（即IDPR）描述自噬途径。它详细介绍了自噬中由无序区域执行的结构和机制功能。通过对自噬生物发生的描述，将货物与自噬机器联系起来，以及对某些翻译后调控的讨论，本综述揭示了IDPR在功能性自噬途径中的许多不可或缺的作用。神经退行性疾病，癌症或糖尿病等毁灭性病理已与IDP / IDPR的故障相关。相同的病理学与功能失调的自噬相关，表明自噬IDPR可能是最重要的病因。本章报道了涉及蛋白质内在障碍的自噬途径的几种疾病相关机制，以说明IDPR在自噬的治疗性调节中的广泛潜力。或糖尿病与IDP / IDPR故障有关。相同的病理学与功能失调的自噬相关，表明自噬IDPR可能是最重要的病因。本章报道了涉及蛋白质内在障碍的自噬途径的几种疾病相关机制，以说明IDPR在自噬的治疗性调节中的广泛潜力。或糖尿病与IDP / IDPR故障有关。相同的病理学与功能失调的自噬相关，表明自噬IDPR可能是最重要的病因。本章报道了涉及蛋白质内在障碍的自噬途径的几种疾病相关机制，以说明IDPR在自噬的治疗性调节中的广泛潜力。