Five compounds (1 -– 5) were isolated from the leaves of Gomphrena celosioides Mart species harvested in Nam Dinh province and studied by chromatographic method. These compounds were identified as cleomiscosin A(1), dictyoceratin- C (2), ilimaquinone (3), bruceolline F (4), and neodactyloquinone (5). Their structures were elucidated by spectroscopic techniques including mass spectrometry (MS) and nuclear magnetic resonance (NMR). These compounds were isolated from the leaves of G. celosioides for the first time. All compounds were evaluated for their hypoglycemic activity in PTP1B inhibition and glucose uptake into 3T3-L1 adipocytes enhancement models. Results showed that compound 5 produced maximum effect with PTP1B inhibitory activity of 80.39 ± 6.88%, IC50 = 42.78 ± 2.86 μM, as well as the strongest ability to enhance glucose uptake in 3T3-L1 adipocytes.

中文翻译：

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从 Gomphrena celosioides Mart 中分离出的化合物的降血糖活性

从南定省收获的 Gomphrena celosioides Mart 物种的叶子中分离出五种化合物 (1 - – 5)，并通过色谱法进行研究。这些化合物被鉴定为 cleomiscosin A(1)、dictyoceratin-C (2)、ilimaquinone (3)、bruceolline F (4) 和新指角醌 (5)。它们的结构通过包括质谱（MS）和核磁共振（NMR）在内的光谱技术阐明。这些化合物是首次从 G. celosioides 的叶子中分离出来。评估了所有化合物在 PTP1B 抑制和葡萄糖摄取到 3T3-L1 脂肪细胞增强模型中的降血糖活性。结果表明化合物5产生最大效果，PTP1B抑制活性为80.39±6.88%，IC50 = 42.78±2.86 μM，