Sporotrichosis zoonotic transmission by cats has obtained hyperendemic magnitude in Rio de Janeiro, Brazil. Atypical cases, relapses, and reinfections as well as reduced diagnostic sensitivity of conventional methods have been reported. Previously, the anti-SsCBF enzyme-linked immunosorbent assay (ELISA) test was shown to be useful as a diagnostic tool for human sporotrichosis. Effective diagnosis and treatment are critical to interrupt the chain of transmission of this major pathogen in Brazilian Public Health. To evaluate its applicability for feline sporotrichosis diagnosis and/or therapeutic follow-up, 15 domestic cats from Rio de Janeiro were clinically and laboratory monitored by cytopathology, culture, Sporothrix genotyping, and anti-SsCBF IgG levels. Subsequently, animals were divided into satisfactory and non-satisfactory therapeutic responders. Averages of antibody serum levels obtained for diagnosis (first consultation) compared with the levels found after follow-up (last consultation) were significantly different in both groups (p = 0.0002 and p = 0.038, respectively). We conclude that the SsCBF ELISA test can predict feline sporotrichosis therapeutic responses even for animals with distinct clinical evolutions.

中文翻译：

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SsCBF ELISA 测试在监测由巴西流行病巴西孢子丝菌引起的猫孢子丝菌病的治疗反应中的应用前景

在巴西里约热内卢，猫的孢子丝菌病人畜共患病传播已达到高度流行的程度。已经报道了非典型病例、复发和再感染以及传统方法诊断敏感性降低的情况。以前，抗 SsCBF 酶联免疫吸附试验 (ELISA) 测试被证明可用作人类孢子丝菌病的诊断工具。有效的诊断和治疗对于阻断这种主要病原体在巴西公共卫生中的传播链至关重要。为了评估其对猫孢子丝菌病诊断和/或治疗随访的适用性，对来自里约热内卢的 15 只家猫进行了细胞病理学、培养、孢子丝菌基因分型和抗 SsCBF IgG 水平的临床和实验室监测。随后，动物被分为满意和不满意的治疗反应者。与随访（最后一次咨询）后发现的水平相比，诊断（第一次咨询）获得的抗体血清水平平均值在两组中显着不同（分别为 p = 0.0002 和 p = 0.038）。我们得出结论，即使对于具有不同临床演变的动物，SsCBF ELISA 测试也可以预测猫孢子丝菌病的治疗反应。