Tissue-resident memory T cells (Trm) comprise the majority of memory cells in nonlymphoid tissues and play a predominant role in immunity at barrier surfaces. A better understanding of Trm cell maintenance and function is essential for the development of vaccines that confer frontline protection. However, it is currently challenging to precisely distinguish Trm cells from other T cells, and this has led to confusion in the literature. Here we highlight gaps in our understanding of tissue memory and discuss recent advances in the classification of Trm cell subsets based on their distribution and functional characteristics.

中文翻译：

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组织记忆 T 细胞的分歧：分布和基于功能的分类。

组织驻留记忆 T 细胞 (Trm) 包含非淋巴组织中的大部分记忆细胞，并在屏障表面的免疫中起主要作用。更好地了解 Trm 细胞的维持和功能对于开发提供一线保护的疫苗至关重要。然而，目前精确区分 Trm 细胞与其他 T 细胞是一项挑战，这导致了文献中的混乱。在这里，我们强调了我们对组织记忆理解的差距，并讨论了基于 Trm 细胞亚群分布和功能特征分类的最新进展。