Periodontal disease (PD) is one of the main causes of tooth loss and is related to oxidative stress and chronic inflammation. Although different treatments have been proposed in the past, the vast majority do not regenerate lost tissues. In this sense, the use of dental pulp mesenchymal stem cells (DPMSCs) seems to be an alternative for the regeneration of periodontal bone tissue. A quasi-experimental study was conducted in a sample of 22 adults between 55 and 64 years of age with PD, without uncontrolled systemic chronic diseases. Two groups were formed randomly: (i) experimental group (EG) , with a treatment based on DPMSCs; and a (ii) control group (CG) , without a treatment of DPMSCs. Every participant underwent clinical and radiological evaluations and measurement of bone mineral density (BMD) by tomography. Saliva samples were taken as well, to determine the total concentration of antioxidants, superoxide dismutase (SOD), lipoperoxides, and interleukins (IL), before and 6 months after treatment. All subjects underwent curettage and periodontal surgery, the EG had a collagen scaffold treated with DPMSCs, while the CG only had the collagen scaffold placed. The EG with DPMSCs showed an increase in the BMD of the alveolar bone with a borderline statistical significance (baseline vs. posttreatment HU, ). Regarding oxidative stress and inflammation markers, salivary SOD levels were significantly higher in EG (baseline vs. posttreatment, ) meanwhile IL1β levels had a decrease (baseline vs. posttreatment , ). Our findings suggest that a DPMSCs treatment based on DPMSCs has both an effect on bone regeneration linked to an increased SOD and decreased levels of IL1β in aging subjects with PD.

中文翻译：

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牙髓间充质干细胞作为老年人牙周疾病的治疗方法。

牙周疾病（PD）是造成牙齿脱落的主要原因之一，与氧化应激和慢性炎症有关。尽管过去已经提出了不同的治疗方法，但是绝大多数不能再生丢失的组织。从这个意义上讲，牙髓间充质干细胞（DPMSC）的使用似乎是牙周骨组织再生的一种替代方法。对22名55至64岁的PD患者进行了准实验研究，这些患者没有不受控制的系统性慢性疾病。随机分为两组：（i）实验组（EG），基于DPMSC的治疗；和（ii）对照组（CG），无需处理DPMSC。每位参与者均接受了X线断层摄影术的临床和放射学评估以及骨矿物质密度（BMD）的测量。在治疗前和治疗后6个月，还采集唾液样本，以确定抗氧化剂，超氧化物歧化酶（SOD），脂过氧化物和白介素（IL）的总浓度。所有受试者均行刮除术和牙周手术，其中EG的胶原蛋白支架经DPMSC处理，而CG仅具有胶原蛋白支架。带有DPMSC的EG显示牙槽骨的BMD增加，具有统计学上的临界值（基线 与后处理 ， ）。关于氧化应激和炎症标志物，EG中唾液SOD水平显着较高（基线 与 后处理 ）同时IL- β水平有下降（基线与后处理， ）。我们的研究结果表明，基于一个的DPMSCs治疗的DPMSCs有链接到提高SOD，降低IL-1的水平骨再生两者的影响β与PD老化科目。