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The Functional Roles of IL-33/ST2 Axis in Ocular Diseases.
Mediators of Inflammation ( IF 4.6 ) Pub Date : 2020-08-18 , DOI: 10.1155/2020/5230716
Yujing Qian 1 , Meifen Zhang 1
Affiliation  

Interleukin-33 (IL-33), an important member of the IL-1 family, plays a pivotal role in regulating immune responses via combining with its receptor suppression of tumorigenicity 2 (ST2). We have already known IL-33/ST2 axis participates in the pathogenesis of various diseases, including liver diseases, renal diseases, and neurological diseases. Recently, emerging studies are indicating that IL-33/ST2 is also involved in a wide range of ocular diseases, such as allergic eye disease, keratitis and corneal regeneration, dry eye disease, uveitis, vitreoretinal diseases, and neuromyelitis optica spectrum disorder. In this review, we will summarize and discuss the current understanding about the functional roles of IL-33/ST2 in eyes, with an attempt to explore the possible study perspectives and therapeutic alternatives in the future.

中文翻译:

IL-33/ST2 轴在眼部疾病中的功能作用。

白细胞介素-33 (IL-33) 是 IL-1 家族的重要成员,通过与其受体抑制致瘤性 2 (ST2) 相结合,在调节免疫反应中发挥着关键作用。我们已经知道IL-33/ST2轴参与各种疾病的发病机制,包括肝脏疾病、肾脏疾病和神经系统疾病。最近,新兴研究表明 IL-33/ST2 还涉及多种眼部疾病,如过敏性眼病、角膜炎和角膜再生、干眼病、葡萄膜炎、玻璃体视网膜疾病和视神经脊髓炎谱系障碍。在这篇综述中,我们将总结和讨论目前对 IL-33/ST2 在眼中的功能作用的理解,以期探索未来可能的研究前景和治疗选择。
更新日期:2020-08-18
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