Dyslipidemia is associated with increased arterial stiffness (AS) which may lead to hypertension. Among the methods to assess AS are carotid-femoral and brachial-ankle pulse wave velocity. Dyslipidemia is also known to trigger inflammation. C-reactive protein (CRP) is one of the commonest inflammatory markers measured in the clinical setting. However, the association between inflammation and pulse wave velocity (PWV) in people with dyslipidemia is less studied. Therefore, this review investigated the association between inflammation (as measured by CRP) and PWV in dyslipidemia patients. The search of the literature was conducted via PubMed and Scopus database. The keywords used were “aortic stiffness” OR “arterial stiffness” OR “pulse wave velocity” OR “vascular stiffness” OR “carotid femoral pulse wave velocity” OR “pulse wave analysis” AND “inflammation” OR “c reactive protein” OR “c-reactive protein” OR “high sensitivity c reactive protein” AND “dyslipidemia” OR “hyperlipidemia” OR “hypercholesterolemia” OR “hyperlipoproteinemia” OR “hypertriglyceridemia”. The following criteria were used: (1) only full-length original articles published in English language, (2) articles that reported the association between arterial stiffness measured as carotid-femoral PWV (cfPWV) or brachial-ankle PWV (baPWV) and CRP or high-sensitivity CRP, and (3) study involving human subjects. The search identified 957 articles published between 1980 and February 2020. Only eight articles fulfilled the inclusion criteria and were used for data extraction. Five of the studies were cross-sectional studies while another three studies were interventional studies. Seven out of eight papers found a significant positive association between AS and CRP, and the correlation ranged from mild to moderate association (Pearson to ). In conclusion, inflammation is associated with increased PWV in patients with dyslipidemia. This supports the involvement of inflammation in the development of AS in dyslipidemia.

中文翻译：

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血脂异常中炎症与脉搏波速度之间的关联：循证综述。

血脂异常与动脉僵硬度（AS）增加有关，可能导致高血压。评估 AS 的方法包括颈动脉-股动脉和臂-踝脉搏波速度。血脂异常也会引发炎症。C反应蛋白（CRP）是临床环境中最常见的炎症标志物之一。然而，血脂异常患者的炎症与脉搏波速度 (PWV) 之间的关系研究较少。因此，本综述调查了血脂异常患者炎症（通过 CRP 测量）与 PWV 之间的关联。通过PubMed和Scopus数据库进行文献检索。使用的关键词是“主动脉僵硬度”或“动脉僵硬度”或“脉搏波速度”或“血管僵硬度”或“颈动脉股动脉脉搏波速度”或“脉搏波分析”和“炎症”或“c反应蛋白”或“ c反应蛋白”或“高敏感性c反应蛋白”和“血脂异常”或“高脂血症”或“高胆固醇血症”或“高脂蛋白血症”或“高甘油三酯血症”。使用以下标准：(1) 仅以英文发表的全文原创文章，(2) 报告以颈动脉-股动脉 PWV (cfPWV) 或臂-踝 PWV (baPWV) 测量的动脉硬度与 CRP 之间关联的文章或高灵敏度 CRP，以及 (3) 涉及人类受试者的研究。检索发现了 1980 年至 2020 年 2 月期间发表的 957 篇文章。只有 8 篇文章符合纳入标准并用于数据提取。其中五项研究是横断面研究，另外三项研究是干预研究。八分之七的论文发现 AS 和 CRP 之间存在显着的正相关，且相关性范围从轻度到中度相关（Pearson到）。总之，炎症与血脂异常患者的 PWV 升高相关。这支持炎症参与血脂异常中 AS 的发展。