Background. To evaluate the ratio of acute kidney injury (AKI) to chronic kidney disease (CKD) in sepsis-associated acute kidney injury (SA-AKI) patients of the intensive care unit (ICU) and predictive value of neutrophil gelatinase-associated lipocalin (NGAL) measured at the admission time in the progression of AKI to CKD. Methods. A study of 121 consecutive adult patients admitted to the intensive care unit (ICU) diagnosed as SA-AKI. AKI and CKD were defined based on Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Glomerular filtration rate (GFR) was calculated by the CKD-EPI formula. Serum and urine NGAL was measured using the BioVendor Human Lipocalin-2/NGAL ELISA with a blood sample taken at hospital admission time. Results. The ratio of AKI to CKD in SA-AKI patients was 22.3%. Mean concentration of serum and urine NGAL in AKI to the CKD group was 790.99 ng/ml and 885.72 ng/ml, higher significantly than those of recovery patients (351.86 ng/ml and 264.68 ng/ml), . eGFR, both serum and urine NGAL had a predictive value for AKI to CKD (eGFR: , , , . Serum NGAL: , , . Urine NGAL: , , , . Conclusion. Serum and urine NGAL, measuring at hospital admission time, were good prognostic biomarkers of AKI to CKD in SA-AKI patients.

中文翻译：

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入院时测量的血清和尿液中性粒细胞明胶酶相关脂质运载蛋白水平可预测脓毒症相关急性肾损伤患者进展为慢性肾病。

背景。评估重症监护病房 (ICU) 脓毒症相关急性肾损伤 (SA-AKI) 患者急性肾损伤 (AKI) 与慢性肾病 (CKD) 的比率及中性粒细胞明胶酶相关载脂蛋白 (NGAL) 的预测价值) 在 AKI 进展为 CKD 的入院时间测量。方法。一项对 121 名被诊断为 SA-AKI 的重症监护病房 (ICU) 连续成年患者进行的研究。AKI 和 CKD 的定义基于肾脏疾病：改善全球结局 (KDIGO) 标准。通过CKD-EPI公式计算肾小球滤过率（GFR）。使用 BioVendor Human Lipocalin-2/NGAL ELISA 测量血清和尿液 NGAL，并在入院时采集血样。结果. SA-AKI 患者 AKI 与 CKD 的比率为 22.3%。AKI至CKD组血清和尿NGAL平均浓度分别为790.99 ng/ml和885.72 ng/ml，明显高于恢复期患者（351.86 ng/ml和264.68 ng/ml），. eGFR、血清和尿液 NGAL 对 AKI 至 CKD 具有预测价值（eGFR：, , , . 血清NGAL：, , . 尿液NGAL：, , , . 结论。入院时测量的血清和尿液 NGAL 是 SA-AKI 患者 AKI 至 CKD 的良好预后生物标志物。