We report a DNA-compatible protocol for synthesizing amides from DNA-bound aldehydes and non-nucleophilic arylamines including aza-substituted anilines, 2-aminobenzimidazoles, and 3-aminopyrazoles. The reactions were carried out at room temperature and provided reasonable conversions and wide functional group compatibility. The reactions were also successful when employing aryl and aliphatic aldehydes. In addition, qPCR and NGS data suggested no negative impact on DNA integrity after the copper-mediated oxidative amidation reaction.

中文翻译：

---

DNA兼容的铜催化醛与非亲核性芳胺的氧化酰胺化反应。

我们报告了从DNA结合的醛和非亲核性芳基胺（包括氮杂取代的苯胺，2-氨基苯并咪唑和3-氨基吡唑）合成酰胺的DNA兼容协议。反应在室温下进行，并提供合理的转化率和广泛的官能团相容性。当使用芳基和脂族醛时，该反应也成功。此外，qPCR和NGS数据表明在铜介导的氧化酰胺化反应后，对DNA完整性没有负面影响。