Replication stress fuels chromosomal instability, tumor heterogeneity and therapy resistance. The Sonic hedgehog pathway is now linked to an unorthodox form of replication stress in cerebellar granular-cell progenitors through deregulated firing of DNA replication origins, with implications for the pathogenesis, genomic instability and treatment of medulloblastoma.

中文翻译：

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髓母细胞瘤中 DNA 合成的超音速

复制应激助长了染色体不稳定性、肿瘤异质性和治疗抗性。Sonic Hedgehog 通路现在与小脑颗粒细胞祖细胞中一种非正统形式的复制应激相关，通过 DNA 复制起点的失调放电，对髓母细胞瘤的发病机制、基因组不稳定性和治疗产生影响。