An antibacterial dental light-cured glass-ionomer cement has been developed and evaluated. An antibacterial furanone derivative was synthesized and covalently attached onto the surface of alumina filler particles. The formed antibacterial fillers were then mixed into a light-curable glass-ionomer cement formulation. Surface hardness and bacterial viability were used to evaluate the modified cements. Effects of coated furanone moiety content on the modified fillers, modified alumina filler particle size and loading, and total glass filler content were investigated. Results showed that increasing antibacterial furanone content, modified particle size and loading, and total glass filler content generally increased surface hardness. Increasing furanone moiety, filler loading and total filler content increased antibacterial activity. On the other hand, increasing particle size decreased antibacterial activity. The leaching tests indicate that the modified experimental cement showed no leachable antibacterial component to bacteria and cells

已经开发和评估了一种抗菌牙科光固化玻璃离聚物水泥。合成了一种抗菌剂呋喃酮衍生物，并将其共价附着在氧化铝填料颗粒的表面上。然后将形成的抗菌填料混合到可光固化的玻璃离聚物水泥配方中。使用表面硬度和细菌生存力评估改性水泥。研究了涂覆的呋喃酮部分含量对改性填料，改性氧化铝填料的粒径和载量以及总玻璃填料含量的影响。结果表明，增加抗菌素呋喃酮的含量，改变粒径和添加量以及总玻璃填料的含量通常会提高表面硬度。呋喃酮部分，填料含量和总填料含量的增加均增加了抗菌活性。另一方面，粒径的增加降低了抗菌活性。浸出试验表明，改性实验水泥对细菌和细胞没有显示出可浸出的抗菌成分。