Abstract

To investigate the value of the combined detection of the neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein level (CRP) in the diagnosis of COVID-19. A total of 191 patients with COVID-19 were recruited at the Third Hospital of Wuhan from 21 January 2020 to 20 February 2020. Fifty healthy volunteers were randomly selected as the control group. Age, gender, white blood cell count (WBC), CRP, lymphocyte percentage, and NLR were extracted. Quantitative clinical characteristics and laboratory values were compared between groups. Risk factors and receiver operating characteristic (ROC) curves for COVID-19 were analyzed. We found that the NLR and CRP were higher, while the lymphocyte percentage was lower in patients with COVID-19 than in healthy controls. Among patients confirmed to have COVID-19, the NLR and CRP of the moderate group were lower than those of severely ill patients (severe, critical and death groups), and the lymphocyte percentage of the moderate group was higher than that of the critical and death group. There were no significant differences in WBC among all groups. Logistic regression analysis showed that the NLR, CRP, and lymphocyte percentage were independent risk factors for COVID-19. The AUC of the combined determination of NLR and CRP was 0.863, which was higher than that of NLR, CRP, WBC, and lymphocyte percentage (AUC: 0.835, 0.775, 0.416, and 0.749, respectively).

Our results showed that the NLR and CRP were independent risk factors for COVID-19, and the combined detection of the NLR and CRP showed improved diagnostic performance for COVID-19.

摘要

探讨中性粒细胞与淋巴细胞比率（NLR）和C反应蛋白水平（CRP）联合检测在诊断COVID-19中的价值。2020年1月21日至2020年2月20日，武汉市第三医院共招募191例COVID-19患者。随机抽取50名健康志愿者作为对照组。提取年龄，性别，白细胞计数（WBC），CRP，淋巴细胞百分比和NLR。比较两组之间的定量临床特征和实验室值。分析了COVID-19的危险因素和接收者操作特征（ROC）曲线。我们发现，与健康对照组相比，COVID-19患者的NLR和CRP较高，而淋巴细胞百分比较低。在确认患有COVID-19的患者中，中度组的NLR和CRP低于重症患者（重度，重度和死亡组），中度组的淋巴细胞百分比高于重度和死亡组。各组之间的白细胞无明显差异。Logistic回归分析显示NLR，CRP和淋巴细胞百分比是COVID-19的独立危险因素。NLR和CRP联合测定的AUC为0.863，高于NLR，CRP，WBC和淋巴细胞百分比的AUC（AUC：分别为0.835、0.775、0.416和0.749）。Logistic回归分析显示NLR，CRP和淋巴细胞百分比是COVID-19的独立危险因素。NLR和CRP联合测定的AUC为0.863，高于NLR，CRP，WBC和淋巴细胞百分比的AUC（AUC：分别为0.835、0.775、0.416和0.749）。Logistic回归分析显示NLR，CRP和淋巴细胞百分比是COVID-19的独立危险因素。NLR和CRP联合测定的AUC为0.863，高于NLR，CRP，WBC和淋巴细胞百分比的AUC（AUC：分别为0.835、0.775、0.416和0.749）。

我们的结果表明，NLR和CRP是COVID-19的独立危险因素，并且对NLR和CRP的联合检测显示对COVID-19的诊断性能有所提高。