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Melt-based, solvent-free additive manufacturing of biodegradable polymeric scaffolds with designer microstructures for tailored mechanical/biological properties and clinical applications
Virtual and Physical Prototyping ( IF 10.6 ) Pub Date : 2020-08-17
Zijie Meng, Jiankang He, Jiaxin Li, Yanwen Su, Dichen Li

Biodegradable scaffolds are considered as the key component of tissue engineering which serve as temporary structural supports for tissue regeneration. The mechanical/biological properties of artificial synthetic polymeric scaffolds are highly dependent on their structural organisations. Additive manufacturing (AM) techniques have provided unprecedented opportunities to customise patient-specific scaffolds with complex architectures in a reproducible manner. Here we provide a state-of-the-art review on the recent development and application of melt-based, solvent-free AM techniques to produce biodegradable polymeric scaffolds for better understanding their structure–property-function relationships for different tissue regeneration. Typical biodegradable polymers for melt-based AM are introduced, and key melt-based AM techniques including extrusion-based printing, selective laser sintering and high-resolution electrohydrodynamic bioprinting are highlighted. The critical strategies by structural design to regulate the mechanical/biological properties of as-fabricated biodegradable scaffolds in vitro and in vivo are summarised. The clinical trials as well as potential challenges of the resultant scaffolds were finally reviewed and discussed.



中文翻译:

基于熔体的无溶剂增材制造具有可设计的微结构的可生物降解的聚合物支架,用于定制的机械/生物学特性和临床应用

可生物降解的支架被认为是组织工程的关键组成部分,可作为组织再生的临时结构支撑。人工合成聚合物支架的机械/生物学特性高度依赖于其结构组织。增材制造(AM)技术提供了前所未有的机会,可以以可重现的方式定制具有复杂架构的患者特定支架。在此,我们提供有关基于熔体的无溶剂AM技术的最新开发和应用的最新技术综述,以生产可生物降解的聚合物支架,以更好地了解其在不同组织再生中的结构-性能-功能关系。介绍了用于熔融基AM的典型可生物降解聚合物,重点介绍了基于熔融的增材制造关键技术,包括基于挤出的印刷,选择性激光烧结和高分辨率电液动力学生物印刷。结构设计的关键策略,用于调节人造生物降解支架的机械/生物学性能总结了体外体内。最后审查并讨论了所得支架的临床试验以及潜在的挑战。

更新日期:2020-08-18
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