Solubility of meloxicam in {acetonitrile + water} mixtures at five temperatures from 293.15 K to 313.15 K has been determined and correlated by means of the Jouyban-Acree model. By using the van’t Hoff and Gibbs equations the respective apparent thermodynamic quantities for the dissolution and mixing processes, namely Gibbs energy, enthalpy, and entropy, were calculated. Non-linear enthalpy–entropy relationship was observed in the plot of enthalpy vs. Gibbs energy exhibiting negative slope in the composition region 0.00 < x ₁ < 0.20 and variant slopes in the other mixtures. Based on the inverse Kirkwood-Buff integrals it follows that meloxicam is preferentially solvated by water molecules in water-rich and acetonitrile-rich mixtures but preferentially solvated by acetonitrile molecules in mixtures 0.26 < x ₁ < 0.60.

已通过Jouyban-Acree模型确定了美洛昔康在293.15 K至313.15 K的五个温度下在{乙腈+水}混合物中的溶解度。通过使用van't Hoff和Gibbs方程，分别计算出溶解和混合过程的表观热力学量，即Gibbs能量，焓和熵。在焓vs图上观察到非线性的焓-熵关系。吉布斯能量在组成区域中表现出负斜率0.00 <  x ₁ <0.20，其他混合物的斜率也不同。根据反柯克伍德-布夫积分，可以得出美洛昔康在富含水和乙腈的混合物中优先被水分子溶剂化，但在混合物中却优选被0.26 < x ₁  <0.60的乙腈分子溶剂化 。