Mitochondrial metabolism must constantly adapt to stress conditions in order to maintain bioenergetic levels related to cellular functions. This absence of proper adaptation can be seen in a wide array of conditions, including cancer. Metabolic adaptation calls on mitochondrial function and draws on the mitochondrial reserve to meet increasing needs. Among mitochondrial respiratory parameters, the spare respiratory capacity (SRC) represents a particularly robust functional parameter to evaluate mitochondrial reserve. We provide an overview of potential SRC mechanisms and regulation with a focus on its particular significance in cancer cells.

中文翻译：

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线粒体备用呼吸能力：未转化细胞和癌细胞的机制、调节和意义

线粒体代谢必须不断适应压力条件，以维持与细胞功能相关的生物能量水平。在包括癌症在内的多种疾病中都可以看到这种缺乏适当适应的情况。代谢适应需要线粒体功能并利用线粒体储备来满足日益增长的需求。在线粒体呼吸参数中，备用呼吸容量 (SRC) 代表了评估线粒体储备的特别强大的功能参数。我们概述了潜在的 SRC 机制和调节，重点是其在癌细胞中的特殊意义。