As a common model for adverse early experience and depression, maternal separation (MS) is always used to investigate the psychological disease. Despite extensive and strong evidence verified the depression-like state induced by MS, little is known about the specific mechanism of MS. Therefore, the present study aimed to investigate the neurobiology mechanism of the MS-induced depression-like state.

中文翻译：

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长时间的母体分离改变了小鼠出生后齿状回的神经发生和突触发生

作为不良早期经历和抑郁症的常见模型，母体分离（MS）总是被用来调查心理疾病。尽管广泛而有力的证据证实了 MS 诱发的抑郁样状态，但对 MS 的具体机制知之甚少。因此，本研究旨在探讨 MS 诱导抑郁样状态的神经生物学机制。