Flexible sensors are essential for advancing implantable and wearable bioelectronics toward monitoring chemical signals within and on the body. Developing biosensors for monitoring multiple neurotransmitters in real time represents a key in vivo application that will increase understanding of information encoded in brain neurochemical fluxes. Here, arrays of devices having multiple In₂O₃ nanoribbon field-effect transistors (FETs) were fabricated on 1.4-μm-thick polyethylene terephthalate (PET) substrates using shadow mask patterning techniques. Thin PET-FET devices withstood crumpling and bending such that stable transistor performance with high mobility was maintained over >100 bending cycles. Real-time detection of the small-molecule neurotransmitters serotonin and dopamine was achieved by immobilizing recently identified high-affinity nucleic-acid aptamers on individual In₂O₃ nanoribbon devices. Limits of detection were 10 fM for serotonin and dopamine with detection ranges spanning eight orders of magnitude. Simultaneous sensing of temperature, pH, serotonin, and dopamine enabled integration of physiological and neurochemical data from individual bioelectronic devices.

柔性传感器对于推动可植入和可穿戴生物电子产品走向监测体内和体内化学信号至关重要。开发用于实时监测多种神经递质的生物传感器代表了一项关键的体内应用，它将增加对大脑神经化学通量编码信息的理解。在此，具有多个In ₂ O ₃的设备阵列使用荫罩图案化技术，在1.4μm厚的聚对苯二甲酸乙二醇酯（PET）基板上制造了纳米带场效应晶体管（FET）。薄的PET-FET器件可以经受起皱和弯曲，从而在超过100个弯曲周期内都能保持稳定的晶体管性能和高迁移率。通过将最近鉴定出的高亲和力核酸适体固定在单个In ₂ O ₃上，可以实时检测小分子神经递质血清素和多巴胺纳米带设备。血清素和多巴胺的检出限为10 fM，检出范围跨越八个数量级。同时感测温度，pH，5-羟色胺和多巴胺可以整合来自单个生物电子设备的生理和神经化学数据。