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Fe-S cluster biogenesis by the bacterial Suf pathway.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ( IF 5.1 ) Pub Date : 2020-08-18 , DOI: 10.1016/j.bbamcr.2020.118829
Matthew Blahut 1 , Enis Sanchez 1 , Claire E Fisher 1 , F Wayne Outten 1
Affiliation  

Biogenesis of iron-sulfur (Fe-S) clusters in an essential process in living organisms due to the critical role of Fe-S cluster proteins in myriad cell functions. During biogenesis of Fe-S clusters, multi-protein complexes are used to drive the mobilization and protection of reactive sulfur and iron intermediates, regulate assembly of various Fe-S clusters on an ATPase-dependent, multi-protein scaffold, and target nascent clusters to their downstream protein targets. The evolutionarily ancient sulfur formation (Suf) pathway for Fe-S cluster assembly is found in bacteria and archaea. In Escherichia coli, the Suf pathway functions as an emergency pathway under conditions of iron limitation or oxidative stress. In other pathogenic bacteria, such as Mycobacterium tuberculosis and Enterococcus faecalis, the Suf pathway is the sole source for Fe-S clusters and therefore is a potential target for the development of novel antibacterial compounds. Here we summarize the considerable progress that has been made in characterizing the first step of mobilization and protection of reactive sulfur carried out by the SufS-SufE or SufS-SufU complex, Fe-S cluster assembly on SufBC2D scaffold complexes, and the downstream trafficking of nascent Fe-S clusters to A-type carrier (ATC) proteins.



中文翻译:

Fe-S簇通过细菌Suf途径生物发生。

由于 Fe-S 簇蛋白在无数细胞功能中的关键作用,铁硫 (Fe-S) 簇在活生物体的一个重要过程中的生物发生。在 Fe-S 簇的生物发生过程中,多蛋白复合物用于驱动活性硫和铁中间体的动员和保护,调节各种 Fe-S 簇在 ATPase 依赖的多蛋白支架上的组装,并靶向新生簇到其下游蛋白质靶标。在细菌和古细菌中发现了 Fe-S 簇组装的进化古老硫形成 (Suf) 途径。在大肠杆菌中,Suf 途径在铁限制或氧化应激条件下起到紧急途径的作用。在其他致病菌中,如结核分枝杆菌粪肠球菌,Suf 途径是 Fe-S 簇的唯一来源,因此是开发新型抗菌化合物的潜在目标。在这里,我们总结了在表征由 SufS-SufE 或 SufS-SufU 复合物、SufBC 2 D 支架复合物上的 Fe-S 簇组装以及下游将新生的 Fe-S 簇运输到 A 型载体 (ATC) 蛋白。

更新日期:2020-08-18
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