Sesbagrandiflorains A (1) and B (2), isolated from the stem bark of the Indonesian fabaceous plant Sesbania grandiflora, were reported to be 6-methoxy-2-(2´,3´-dihydroxy-5´-methoxyphenyl)-1-benzofuran-3-carbaldehyde and 6-hydroxy-2-(2´,3´-dihydroxy-5´-methoxyphenyl)-1-benzofuran-3-carbaldehyde, respectively. However, based on reevaluation of their 1D and 2D NMR data, the chemical structures of 1 and 2 have been revised to 4-hydroxy-2-(4´-hydroxy-2´-methoxyphenyl)-6-methoxybenzofuran-3-carbaldehyde and 4-hydroxy-2-(4´-hydroxy-2´-hydroxyphenyl)-6-methoxybenzofuran-3-carbaldehyde, respectively. In addition, seven new derivatives of 1 have been synthesized from the natural product in good yields (65 − 93%). The chemical structures of the synthetic compounds—one diester (6), four ethers (7–10), one secondary amine (11), and one oxime (12)—were confirmed by MS and NMR analysis. Compound 6 exhibited moderate antibacterial activity against the plant pathogen Rhodococcus fascians with a MIC of 0.1 mg/mL. Compounds 8 and 12 demonstrated respectable cytotoxicity against A375 melanoma cancer cells line with the relative IC₅₀ values of 22.8 and 32.7 μM, respectively.

据报道，从印度尼西亚豆科植物Sesbania grandiflora的茎皮中分离出的 Sesbagrandiflorrains A (1) 和 B (2)是 6-methoxy-2-(2´,3´-dihydroxy-5´-methoxyphenyl)-1分别为 -benzofuran-3-carbaldehyde 和 6-hydroxy-2-(2´,3´-dihydroxy-5´-methoxyphenyl)-1-benzofuran-3-carbaldehyde。然而，基于对 1D 和 2D NMR 数据的重新评估，1 和 2 的化学结构已修改为 4-hydroxy-2-(4´-hydroxy-2´-methoxyphenyl)-6-methoxybenzofuran-3-carbaldehyde 和分别为 4-羟基-2-(4´-羟基-2´-羟基苯基)-6-甲氧基苯并呋喃-3-甲醛。此外，1的 7 个新衍生品已从天然产物中以良好的收率 (65 - 93%) 合成。合成化合物的化学结构——一种二酯 (6)、四种醚 (7-10)、一种仲胺 (11) 和一种肟 (12)——通过 MS 和 NMR 分析得到证实。化合物 6 对植物病原体Rhodococcus fascians表现出中等的抗菌活性，MIC 为 0.1 mg/mL。化合物 8 和 12 对 A375 黑色素瘤癌细胞系表现出可观的细胞毒性，其相对 IC ₅₀值分别为 22.8 和 32.7 μM。