It was aimed to evaluate serum zinc and copper levels and oxidative stress parameters in ectopic pregnancy cases, healthy pregnant women, and healthy non-pregnant women. In this cross-sectional case-control study, 30 patients diagnosed with tubal ectopic pregnancy in the gynecology clinic of a tertiary hospital constituted the study group. A healthy pregnant control group (n = 30) was formed of age, body mass index (BMI), and gestational week-matched subjects, and a healthy non-pregnant control group (n = 30) was formed of age and BMI-matched women. The groups were compared in terms of demographic characteristics and laboratory parameters including serum zinc (Zn) level, serum copper (Cu) level, serum malondialdehyde (MDA) level, serum catalase (CAT) activity, serum glutathione peroxidase (GPX) activity, and serum superoxide dismutase (SOD) activity. The groups were similar in respect of demographic characteristics. In the ectopic pregnancy group, serum GPX activity and Cu level were significantly lower, and serum SOD and CAT activity and Zn and MDA levels were higher compared with those of the healthy pregnant and healthy non-pregnant groups. The Cu/Zn ratio showed a significant, positive correlation with the serum GPX activity and serum progesterone level and a negative correlation with serum SOD and CAT activity. When 1.14 was taken as the cutoff value, sensitivity and specificity of the Cu/Zn ratio to determine ectopic pregnancy were 73.3% and 80.0%, respectively. Comparing the area under curve (AUC) in the ROC (receiver operating characteristic) curve analysis, the Cu/Zn ratio was determined to be more valuable than the Cu or Zn values alone in predicting ectopic pregnancy. In correlation analysis, serum beta hCG level showed a negative correlation with SOD and CAT activities and Zn levels. Serum progesterone level showed a negative correlation with serum CAT and SOD activities and MDA and zinc levels and a positive correlation with serum GPX activity and serum copper level (p < 0.05 for all). The current study can be considered of value as the first study in literature to show a significantly lower serum Zn level and higher serum Cu level in ectopic pregnancy cases compared with healthy pregnant control cases. This is also the first study to have revealed an association between the serum Cu/Zn ratio, oxidative status, and ectopic pregnancy. Furthermore, the serum Cu/Zn ratio was found to be useful in the diagnosis of ectopic pregnancy cases.

目的是评估异位妊娠病例，健康孕妇和健康非孕妇中的血清锌和铜水平以及氧化应激参数。在该横断面病例对照研究中，由三级医院妇科门诊诊断为输卵管异位妊娠的30名患者组成了研究组。甲健康孕妇对照组（Ñ = 30）中的年龄形成，身体质量指数（BMI）和妊娠周匹配的受试者，和健康非妊娠对照组（Ñ= 30）由年龄和BMI匹配的女性组成。比较两组的人口统计学特征和实验室参数，包括血清锌（Zn）水平，血清铜（Cu）水平，血清丙二醛（MDA）水平，血清过氧化氢酶（CAT）活性，血清谷胱甘肽过氧化物酶（GPX）活性和血清超氧化物歧化酶（SOD）活性。两组在人口特征方面相似。与健康孕妇和健康非孕妇组相比，异位妊娠组的血清GPX活性和Cu水平明显降低，血清SOD和CAT活性以及Zn和MDA水平较高。Cu / Zn比值与血清GPX活性和血清孕酮水平呈显着正相关，与血清SOD和CAT活性呈负相关。当1。以14为临界值，Cu / Zn比值的敏感性和特异性分别为73.3％和80.0％。比较ROC（接收器工作特性）曲线分析中的曲线下面积（AUC），在预测异位妊娠中，确定的Cu / Zn比值比单独的Cu或Zn值更有价值。在相关分析中，血清βhCG水平与SOD和CAT活性以及锌水平呈负相关。血清孕酮水平与血清​​CAT和SOD活性以及MDA和锌水平呈负相关，与血清GPX活性和血清铜水平呈正相关（比较ROC（接收器工作特性）曲线分析中的曲线下面积（AUC），在预测异位妊娠中，确定的Cu / Zn比值比单独的Cu或Zn值更有价值。在相关分析中，血清βhCG水平与SOD和CAT活性以及锌水平呈负相关。血清孕酮水平与血清​​CAT和SOD活性以及MDA和锌水平呈负相关，与血清GPX活性和血清铜水平呈正相关（比较ROC（接收器工作特性）曲线分析中的曲线下面积（AUC），在预测异位妊娠中，确定的Cu / Zn比值比单独的Cu或Zn值更有价值。在相关分析中，血清βhCG水平与SOD和CAT活性以及锌水平呈负相关。血清孕酮水平与血清​​CAT和SOD活性以及MDA和锌水平呈负相关，与血清GPX活性和血清铜水平呈正相关（均p <0.05）。当前的研究可被认为是有价值的文献，其显示与健康的怀孕对照组相比，异位妊娠患者的血清Zn水平明显降低，而血清Cu的水平升高，这是文献中的第一项研究。这也是第一个揭示血清铜/锌比，氧化状态和异位妊娠之间相关性的研究。此外，发现血清铜/锌比可用于诊断异位妊娠病例。