Social isolation, a risk factor for poor health within the general population, may be exacerbated by unique challenges faced by people living with HIV (PLHIV). This analysis examines the association between social isolation and all-cause mortality among a cohort of PLHIV experiencing multiple social vulnerabilities. The analytical sample included 936 PLHIV ≥ 19 years, living in British Columbia, Canada, and enrolled in the Longitudinal Investigation into Supportive and Ancillary Health Services (LISA) Study (2007-2010). Participants were classified as Socially Connected (SC), Minimally Isolated (MI) or Socially Isolated (SI) via latent class analysis. Cross-sectional survey data was linked to longitudinal clinical data from a provincial HIV treatment database. Mortality was assessed longitudinally up to and including December 31st, 2017. Through multivariable logistic regression, an association between SI and all-cause mortality was found (adjusted OR: 1.48; 95% CI 1.08, 2.01). These findings emphasize the need to mitigate effects of social isolation among PLHIV.

中文翻译：

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加拿大不列颠哥伦比亚省艾滋病毒感染者的社会隔离和死亡率。

艾滋病病毒感染者（PLHIV）面临的独特挑战可能加剧社会隔离，这是普通人群健康状况不佳的危险因素。该分析检查了一群患有多种社会脆弱性的艾滋病病毒感染者之间的社会隔离与全因死亡率之间的关系。分析样本包括居住在加拿大不列颠哥伦比亚省的936名≥19岁的PLHIV，并参加了支持和辅助健康服务（LISA）纵向研究（2007-2010年）。通过潜在类别分析将参与者分为社交联系（SC），最小孤立（MI）或社交孤立（SI）。横断面调查数据与省级艾滋病治疗数据库的纵向临床数据相关联。截至2017年12月31日（含），对死亡率进行了纵向评估。通过多变量logistic回归，发现SI与全因死亡率之间存在关联（校正OR：1.48； 95％CI 1.08，2.01）。这些发现强调必须减轻艾滋病病毒感染者之间的社会隔离的影响。