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Evidence-based approach to setting delta check rules
Critical Reviews in Clinical Laboratory Sciences ( IF 10.0 ) Pub Date : 2020-08-14 , DOI: 10.1080/10408363.2020.1800585
Corey Markus 1 , Rui Zhen Tan 2 , Tze Ping Loh 3
Affiliation  

Abstract

Delta checks are a post-analytical verification tool that compare the difference in sequential laboratory results belonging to the same patient against a predefined limit. This unique quality tool highlights a potential error at the individual patient level. A difference in sequential laboratory results that exceeds the predefined limit is considered likely to contain an error that requires further investigation that can be time and resource intensive. This may cause a delay in the provision of the result to the healthcare provider or entail recollection of the patient sample. Delta checks have been used primarily to detect sample misidentification (sample mix-up, wrong blood in tube), and recent advancements in laboratory medicine, including the adoption of protocolized procedures, information technology and automation in the total testing process, have significantly reduced the prevalence of such errors. As such, delta check rules need to be selected carefully to balance the clinical risk of these errors and the need to maintain operational efficiency. Historically, delta check rules have been set by professional opinion based on reference change values (biological variation) or the published literature. Delta check rules implemented in this manner may not inform laboratory practitioners of their real-world performance. This review discusses several evidence-based approaches to the optimal setting of delta check rules that directly inform the laboratory practitioner of the error detection capabilities of the selected rules. Subsequent verification of workflow for the selected delta check rules is also discussed. This review is intended to provide practical assistance to laboratories in setting evidence-based delta check rules that best suits their local operational and clinical needs.



中文翻译:

设置增量检查规则的循证方法

摘要

Delta 检查是一种分析后验证工具,可将属于同一患者的连续实验室结果的差异与预定义的限制进行比较。这种独特的质量工具突出了个体患者级别的潜在错误。超过预定义限制的连续实验室结果的差异被认为可能包含需要进一步调查的错误,这可能是时间和资源密集型的。这可能会导致向医疗保健提供者提供结果的延迟或需要重新收集患者样本。Delta 检查主要用于检测样本错误识别(样本混淆、试管中的血液错误)以及实验室医学的最新进展,包括采用协议程序、整个测试过程中的信息技术和自动化显着降低了此类错误的发生率。因此,需要仔细选择增量检查规则,以平衡这些错误的临床风险和保持运营效率的需要。历史上,delta 检查规则是根据参考变化值(生物变异)或已发表的文献由专业意见制定的。以这种方式实施的 Delta 检查规则可能不会告知实验室从业人员他们的实际表现。本综述讨论了几种基于证据的方法来优化设置 delta 检查规则,这些方法直接通知实验室从业人员所选规则的错误检测能力。还讨论了所选增量检查规则的工作流的后续验证。

更新日期:2020-08-14
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