Transcription of DNA into mRNA and translation of mRNA into proteins are two major processes underlying gene expression. Due to the distinct molecular mechanisms, timings, and locales of action, these processes are mainly considered to be independent. During the last two decades, however, multiple factors and elements were shown to coordinate transcription and translation, suggesting an intricate level of synchronization. This review discusses the molecular mechanisms that impact both processes in eukaryotic cells of different origins. The emerging global picture suggests evolutionarily conserved regulation and coordination between transcription and mRNA translation, indicating the importance of this phenomenon for the fine‐tuning of gene expression and the adjustment to constantly changing conditions.

中文翻译：

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如此接近，无论多远：在真核生物中连接转录与 mRNA 翻译的多条路径。

DNA 转录为 mRNA 和 mRNA 翻译为蛋白质是基因表达的两个主要过程。由于不同的分子机制、时间和作用场所，这些过程主要被认为是独立的。然而，在过去的二十年里，多个因素和元素被证明可以协调转录和翻译，表明同步的复杂程度。本综述讨论了影响不同来源真核细胞中这两个过程的分子机制。新兴的全球图景表明转录和 mRNA 翻译之间的进化保守调控和协调，表明这种现象对于基因表达的微调和对不断变化的条件的调整的重要性。