Bacteria-induced infections have always been associated with various medical devices. The construction of an intelligent antimicrobial surface is an important challenge. In this study, we report the construction of a zwitterionic surface with good biocompatibility under physiological conditions and which shows an anti-adhesion effect on the original bacteria. Once the bacteria multiply, the acidic environment initiated by the bacteria will cause the amide bond on the surface to break, and the zwitterionic surface can be rapidly converted to a cationic bactericidal surface. Confocal laser scanning (CLSM) and scanning electron microscopy (SEM) show that the zwitterionic surface has efficient antibacterial activity with an anti-adhesion property while the pH-responsive transition to quaternary ammonium compounds with a germicidal surface in the acidic environment of bacterial metabolism aids the activity. Thus, the pH-responsive zwitterionic-to-cationic transition antibacterial design opens up new ideas for the efficient and safe application of cationic bactericides in clinical medical antibacterial materials.

中文翻译：

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pH响应的两性离子到阳离子的过渡，可实现安全的自卫性抗菌应用

细菌引起的感染一直与各种医疗设备有关。智能抗菌表面的构建是一个重要的挑战。在这项研究中，我们报告了在生理条件下具有良好生物相容性的两性离子表面的构建，并且该表面对原始细菌具有抗粘附作用。一旦细菌繁殖，由细菌引发的酸性环境将导致表面上的酰胺键断裂，两性离子表面可迅速转化为阳离子杀菌表面。共聚焦激光扫描（CLSM）和扫描电子显微镜（SEM）表明，两性离子表面在细菌代谢辅助剂的酸性环境中具有有效的抗菌活性和抗粘着性，而pH响应转变为具有杀菌表面的季铵化合物。活动。因此，pH响应的两性离子-阳离子过渡抗菌设计为阳离子杀菌剂在临床医用抗菌材料中的高效安全应用开辟了新思路。