Ureteral stents have been widely used as biomedical devices to treat some urological diseases for several decades. However, the encrustation complications hamper the long-time clinical use of the ureteral stents. In this work, a new type of biodegradable material for the ureteral stents, methoxypoly(ethylene glycol)-block-poly(L-lactide-ran-Ɛ-caprolactone) (mPEG-PLACL), is evaluated to overcome this problem. The results show that the hydrophilicity and degradation rate in artificial urine of mPEG-PLACL are both significantly increased. It is worth noting that the mPEG-PLACL shows a lower amount of encrustation after immersing the stents in the dynamic urinary extracorporeal circulation (DUEC) model for 7 days. In addition, 71% Ca and 92% Mg are inhibited in vivo by quantitative analysis. Pathological analysis exhibit that the mPEG-PLACL cause less diffuse mucosal hyperplasia after 7 weeks of implantation. All the results indicate that this new type of biodegradable material had an excellent potential for the ureteral stents in the future.

几十年来，输尿管支架作为生物医学装置被广泛用于治疗一些泌尿系统疾病。然而，结壳并发症阻碍了输尿管支架的长期临床使用。在这项工作中，评估了一种用于输尿管支架的新型生物可降解材料甲氧基聚（乙二醇）-嵌段-聚（L-丙交酯-ran-Ɛ-己内酯）（mPEG-PLACL）来克服这个问题。结果表明，mPEG-PLACL在人工尿液中的亲水性和降解率均显着提高。值得注意的是，在将支架浸入动态尿体外循环 (DUEC) 模型 7 天后，mPEG-PLACL 显示出较低的结垢量。此外，71% Ca 和 92% Mg在体内被抑制通过定量分析。病理分析表明，mPEG-PLACL 在植入 7 周后引起较少的弥漫性粘膜增生。所有结果表明，这种新型生物可降解材料在未来用于输尿管支架方面具有极好的潜力。