After bone prosthesis replacement, M1‐type macrophage polarization can be induced by titanium (Ti) particles and produce inflammatory, leading to osteolysis. Adipocyte‐derived exosomes (ADEs) exert immune‐modulatory impact on the macrophage, while whether it can inhibit the macrophage polarization induced by Ti is unclear. This study focuses on the M1‐type macrophage and aims to determine the effect of ADEs on Ti‐induced M1‐type macrophage polarization in osteolytic mice and the involved mechanism.

中文翻译：

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脂肪细胞外泌体携带的miR-34a抑制小鼠骨质溶解模型中M1巨噬细胞的极化

假体置换后，钛 (Ti) 颗粒可诱导 M1 型巨噬细胞极化并产生炎症，导致骨质溶解。脂肪细胞衍生的外泌体（ADEs）对巨噬细胞产生免疫调节作用，但是否能抑制Ti诱导的巨噬细胞极化尚不清楚。本研究侧重于 M1 型巨噬细胞，旨在确定 ADEs 对溶骨小鼠 Ti 诱导的 M1 型巨噬细胞极化的影响及其相关机制。