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Recent Advances in Fluorescence Light‐Up Endogenous and Exogenous Carbon Monoxide Detection in Biology
Chemistry - An Asian Journal ( IF 4.1 ) Pub Date : 2020-08-17 , DOI: 10.1002/asia.202000892
Sujay Mukhopadhyay 1 , Arnab Sarkar 1 , Pabitra Chattopadhyay 1 , Koushik Dhara 2
Affiliation  

Considerable attention has been paid by the scientific community to detect toxic carbon monoxide (CO) in sub‐cellular organelles like mitochondria, lysosomes, nuclei, etc. due to their generation and accumulation through numerous biological processes and their role as signal transducer, therapeutics, etc. Various methods are also available for detection of CO, but fluorescence light‐up detection is considered the best due to its easy and accurate sensing capability. As of now, no review is available in the literature dedicated to fluorescent detection of only CO both in vitro and in vivo, but considering the huge amount of work reporting every year, it is necessary to have an account of all the recent significant works devoted to it. This review will give special attention to the most noteworthy development of fluorescent light‐up probes for the detection of cellular and sub‐cellular targetable CO starting from 2012 and emphasizing also the mechanism of action and the applications.

中文翻译:

荧光发光内源性和外源性一氧化碳生物学检测的最新进展

由于它们是通过许多生物过程生成和积累的,并且它们在信号转导,治疗,治疗等方面的作用,科学界已经非常重视检测线粒体,溶酶体,细胞核等亚细胞器中的有毒一氧化碳(CO)。 CO的检测方法也多种多样,但由于荧光灯检测具有简便而准确的检测能力,因此被认为是最好的方法。到目前为止,在专门针对荧光法检测体内和体外CO的文献中,尚无任何综述,但是考虑到每年报告的工作量很大,有必要对所有最近的重要工作进行说明。对此。
更新日期:2020-10-17
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