Hydrogels enable a variety of applications due to their dynamic networks, structural flexibility, and tailorable functionality. However, their mechanical performances are limited, specifically in the context of cellular mechanobiology. It is also difficult to fabricate robust gel networks with a long‐term durability. Thus, a new generation of soft materials showing outstanding mechanical behavior for mechanobiology applications is highly desirable. We combined synthetic biology and supramolecular assembly to prepare elastin‐like protein (ELP) organogel fibers with extraordinary mechanical properties. The mechanical performance and stability of the assembled anisotropic proteins are superior to other organo‐/hydrogel systems. Bone‐derived mesenchymal cells were introduced into the organofiber system for stem‐cell lineage differentiation. This approach demonstrates the feasibility of mechanically strong and anisotropic organonetworks for mechanobiology applications and holds great potential for tissue‐regeneration translations.

中文翻译：

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各向异性蛋白质有机纤维编码的机械力学生物学性能异常。

水凝胶具有动态网络，结构灵活性和可定制的功能，因此可实现多种应用。但是，它们的机械性能受到限制，特别是在细胞力学生物学的情况下。制造具有长期耐久性的坚固的凝胶网络也很困难。因此，非常需要显示出对机械生物学应用优异的机械性能的新一代软材料。我们将合成生物学和超分子组装相结合，制备出具有非凡机械性能的类弹性蛋白（ELP）有机凝胶纤维。组装的各向异性蛋白质的机械性能和稳定性优于其他有机/水凝胶系统。将骨源间充质细胞引入有机纤维系统中，以分化干细胞系。