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Influence of nanofiber alignment on the release of a water-soluble drug from cellulose acetate nanofibers
Saudi Pharmaceutical Journal ( IF 4.1 ) Pub Date : 2020-08-17 , DOI: 10.1016/j.jsps.2020.08.011
Prasopchai Patrojanasophon , Siripran Tidjarat , Praneet Opanasopit , Tanasait Ngawhirunpat , Theerasak Rojanarata

Cellulose acetate nanofibers with different degrees of alignment (randomly aligned (RA), partially aligned (PA), and highly aligned (HA)) were produced using an electrospinning technique. The different degrees of alignment were obtained by adjusting the rotation speed of the collector. Alpha-arbutin (3% w/w) employed as a model water-soluble compound was incorporated into the nanofibers during the fabrication process. The drug release characteristics were investigated using the nanofiber mats with the same size and weight. The prepared nanofibers with different degrees of alignment showed similar physical characteristics, including the fiber diameter, drug loading efficiency and capacity, and molecular form of the drug in the fibers. Interestingly, alpha-arbutin was released from HA nanofibers at a significantly faster rate than the PA and RA nanofibers. Eighty percent of the drug was released into the medium in 1.7, 4.2, and 9.4 min for HA, PA, and RA nanofibers, respectively. The orientation of nanofibers played a crucial role in governing the drug release, probably by creating network meshes with different degrees of entanglement, affecting the diffusion of drug to the external medium. Consequently, this approach can be used as a simple means of achieving immediate-release or fast-acting characteristics of cellulose-based formulations containing a water-soluble drug.



中文翻译:

纳米纤维排列对醋酸纤维素纳米纤维中水溶性药物释放的影响

使用静电纺丝技术生产了具有不同排列度(随机排列(RA),部分排列(PA)和高度排列(HA))的醋酸纤维素纳米纤维。通过调整收集器的旋转速度可以获得不同程度的对准。在制造过程中,将用作模型水溶性化合物的α-熊果苷(3%w / w)掺入到纳米纤维中。使用具有相同尺寸和重量的纳米纤维垫来研究药物释放特性。所制备的具有不同取向度的纳米纤维表现出相似的物理特性,包括纤维直径,药物装载效率和容量以及药物在纤维中的分子形式。有趣的是 α-熊果苷从HA纳米纤维中的释放速度明显快于PA和RA纳米纤维。对于HA,PA和RA纳米纤维,分别在1.7、4.2和9.4分钟内将80%的药物释放到介质中。纳米纤维的取向在控制药物释放中起着至关重要的作用,可能是通过创建具有不同缠结程度的网状网眼来影响药物向外部介质的扩散。因此,该方法可以用作获得含有水溶性药物的纤维素基制剂的立即释放或速效特性的简单方法。可能是通过创建具有不同程度纠缠度的网络网格来影响药物向外部介质的扩散。因此,该方法可以用作获得含有水溶性药物的纤维素基制剂的立即释放或速效特性的简单方法。可能是通过创建具有不同程度纠缠度的网络网格来影响药物向外部介质的扩散。因此,该方法可以用作获得含有水溶性药物的纤维素基制剂的立即释放或速效特性的简单方法。

更新日期:2020-08-17
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