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Divergent evolution and purifying selection of the Type 2 diabetes gene sequences in Drosophila: a phylogenomic study
Genetica ( IF 1.5 ) Pub Date : 2020-08-17 , DOI: 10.1007/s10709-020-00101-7
Manoj Kumar Gupta 1 , Ramakrishna Vadde 1
Affiliation  

The recently developed phylogenomic approach provides a unique way to identify disease risk or protective allele in any organism. While risk alleles evolve mostly under purifying selection, protective alleles are evolving either under balancing or positive selection. Owing to insufficient information, authors employed the phylogenomic approach to detect the nature of selection acting on type 2 diabetes (T2D) genes in Drosophila genus using various models of CODEML utility of PAML. The obtained result revealed that T2D gene sequences are evolving under purifying selection. However, only a few sites in membrane proteins encoded via CG8051, ZnT35C, and kar, are significantly evolving under positive selection under specific scenarios, which might be because of positive or adaptive evolution in response to changing niche, diet or other factors. In the near future, this information will be highly useful in the field of evolutionary medicine and the drug discovery process.

中文翻译:

果蝇 2 型糖尿病基因序列的分化进化和纯化选择:系统发育研究

最近开发的系统基因组学方法提供了一种独特的方法来识别任何生物体中的疾病风险或保护性等位基因。虽然风险等位基因主要在纯化选择下进化,但保护性等位基因在平衡或正选择下进化。由于信息不足,作者采用系统基因组学方法来检测作用于果蝇属 2 型糖尿病 (T2D) 基因的选择性质,使用 PAML 的各种 CODEML 效用模型。获得的结果表明,T2D 基因序列正在纯化选择下进化。然而,在特定情况下,通过 CG8051、ZnT35C 和 kar 编码的膜蛋白中只有少数位点在正选择下显着进化,这可能是因为响应于不断变化的生态位、饮食或其他因素的积极或适应性进化。
更新日期:2020-08-17
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