Epidermal resident γδ T cells, or dendritic epidermal T cells (DETCs) in mice, are a unique and conserved population of γδ T cells enriched in the epidermis, where they serve as the regulators of immune responses and sense skin injury. Despite the great advances in the understanding of the development, homeostasis, and function of DETCs in the past decades, the origin and the underlying molecular mechanisms remain elusive. Here, we reviewed the recent research progress on DETCs, including their origin and homeostasis in the skin, especially at transcriptional and epigenetic levels, and discuss the involvement of DETCs in skin diseases.

中文翻译：

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表皮常驻γδT细胞在皮肤中的发育和功能。

小鼠中的表皮常驻γδT细胞或树突状表皮T细胞（DETC）是富含表皮的独特且保守的γδT细胞群体，它们充当免疫反应和感觉皮肤损伤的调节剂。尽管在过去的几十年中，人们对DETC的发展，体内稳态和功能的理解有了很大的进步，但其起源和潜在的分子机制仍然难以捉摸。在这里，我们回顾了有关DETC的最新研究进展，包括其在皮肤中的起源和体内稳态，尤其是在转录和表观遗传水平上，并讨论了DETC在皮肤疾病中的参与。