A series of curcumin analogs (1-3) were newly designed and synthesized for the development of therapeutic agents for osteoporosis. Among the synthesized compounds, 2,5-substituted conjugated thiophene derivative (1a) and the corresponding pyrazine derivative (1c) were shown to be potential leads for the development of anti-osteoclastogenesis agent.

中文翻译：

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新型姜黄素类似物抑制破骨细胞原的合成及生物学评价

一系列姜黄素类似物（的1 - 3 ）的新设计以及用于骨质疏松症治疗剂的开发合成。在合成的化合物中，已表明2,5-取代的共轭噻吩衍生物（1a ）和相应的吡嗪衍生物（1c ）是开发抗破骨细胞剂的潜在先导。