Background. Information regarding the impact of cardiovascular (CV) conditions on disease progression among patients with mild coronavirus disease 2019 (COVID-19) is limited. Methods. This study evaluated the association of underlying CV conditions with disease progression in patients with mild COVID-19. The primary outcome was the need to be transferred to the designated hospital for intensive care due to COVID-19 disease progression. The patients were divided into with and without CV conditions as well as stable and intensive care groups. Results. Of the 332 patients with mild COVID-19, the median age was 51 years (IQR, 40-59 years), and 200 (61.2%) were female. Of the 48 (14.5%) patients with CV conditions, 23 (47.9%) progressed to severe disease status and required intensive care. Compared with patients without CV conditions, patients with CV conditions were older and more likely to have fatigue, chest tightness, and myalgia. The rate of requiring intensive care was significantly higher among patients with CV conditions than in patients without CV conditions (47.92% vs. 12.4%; ). In subgroup analysis, the rate of requiring intensive care was also higher among patients with either hypertension or coronary heart disease (CHD) than in patients without hypertension or CHD. The multivariable regression model showed that CV condition served as an independent risk factor for intensive care (odds ratio (OR), 2.652 (95% CI, 1.019-6.899)) after adjustment for various cofounders. Conclusions. Patients with mild COVID-19 complicating CV conditions are susceptible to develop severe disease status and requirement for intensive care.

中文翻译：

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轻度 COVID-19 患者心血管负担与重症监护需求之间的关联。

背景。关于心血管 (CV) 状况对 2019 年轻度冠状病毒病 (COVID-19) 患者疾病进展影响的信息有限。方法。本研究评估了轻度 COVID-19 患者潜在心血管疾病与疾病进展的关系。主要结果是由于 COVID-19 疾病进展需要转移到指定医院接受重症监护。将患者分为有和没有心血管疾病以及稳定和重症监护组。结果. 在 332 名轻度 COVID-19 患者中，中位年龄为 51 岁（IQR，40-59 岁），200 名（61.2%）为女性。在 48 名 (14.5%) 患有心血管疾病的患者中，23 名 (47.9%) 进展为严重疾病状态并需要重症监护。与没有心血管疾病的患者相比，有心血管疾病的患者年龄更大，更容易出现疲劳、胸闷和肌痛。有心血管疾病的患者需要重症监护的比率显着高于无心血管疾病的患者（47.92% vs. 12.4%；）。在亚组分析中，患有高血压或冠心病（CHD）的患者需要重症监护的比率也高于没有高血压或冠心病的患者。多变量回归模型显示，在对各种联合创始人进行调整后，CV 状况是重症监护的独立危险因素（优势比 (OR)，2.652 (95% CI，1.019-6.899)）。结论。患有轻度 COVID-19 并发心血管疾病的患者容易发展为严重的疾病状态并需要重症监护。