Bone defects or fractures generally heal in the absence of major interventions due to the high regenerative capacity of bone tissue. However, in situations of severe/large bone defects, these orchestrated regeneration mechanisms are impaired. With advances in modern medicine, natural and synthetic bio-scaffolds from bioceramics and polymers that support bone growth have emerged and gained intense research interest. In particular, scaffolds that recapitulate the molecular cues of extracellular signals, particularly growth factors, offer potential as therapeutic bone biomaterials. The current challenges for these therapies include the ability to engineer materials that mimic the biological and mechanical properties of the real bone tissue matrix, whilst simultaneously supporting bone vascularization. In this review, we discuss the very recent innovative strategies in bone biomaterial technology, including those of endogenous biomaterials and cell/drug delivery systems that promote bone regeneration. We present our understanding of their current value and efficacy, and the future perspectives for bone regenerative medicine.

由于骨组织的高再生能力，在没有重大干预的情况下，骨缺损或骨折通常可以he愈。但是，在严重/大型骨缺损的情况下，这些精心设计的再生机制会受到损害。随着现代医学的进步，来自生物陶瓷的天然和合成生物支架以及支持骨骼生长的聚合物已经出现并引起了广泛的研究兴趣。特别地，概括细胞外信号，特别是生长因子的分子线索的支架，提供了作为治疗性骨生物材料的潜力。这些疗法当前面临的挑战包括工程化能够模仿真实骨骼组织基质的生物学和机械特性的材料，同时支持骨骼血管形成的能力。在这篇评论中 我们将讨论骨骼生物材料技术中的最新创新策略，包括促进骨骼再生的内源性生物材料和细胞/药物输送系统。我们介绍我们对它们的当前价值和功效的了解，以及骨再生医学的未来前景。