We propose in this review that hormesis, a concept profoundly and systematically addressed by Mark Mattson, has to be considered a sort of comprehensive “contact point” capable of unifying several conceptualizations of the aging process, including those focused on the stress response, oxidative stress and chronic inflammation/inflammaging. A major strength of hormesis and inflammaging is that both have a strong evolutionary basis. Moreover, both hormesis and inflammaging frame the aging process within a lifelong perspective of adaptation to different types of stresses. Such adaptation perspective also suggests that the aging process is malleable, and predicts that effective anti-aging strategies should mimic what evolution did on the course of million years and that we have to learn how to exploit the great potential inherent in the hormetic/inflammatory responses. To this regard, new topics such as the production of mitokines to cope with mitochondrial dysfunction are emerging as possible anti-aging target. This approach opens theoretically the door to the possibility of modulate the individual aging rate and trajectory by adopting the most effective scientifically-based lifestyle regarding fundamentally nutrition and physical activity. In this scenario Mark Mattson’s lesson and personal example will permanently enlighten the aging field and the quest for a healthy aging and longevity.

我们在这篇评论中建议，由马克·马特森（Mark Mattson）深刻而系统地解决了兴奋剂这一概念，必须将其视为一种能够统一若干衰老过程概念的综合“接触点”，包括侧重于压力响应，氧化应激的概念。和慢性发炎/发炎。兴奋和发炎的主要优点是两者都有很强的进化基础。而且，兴奋剂和发炎都在适应不同类型压力的终生视角内构筑了衰老过程。这种适应性观点也表明衰老过程是可延展的，并预测有效的抗衰老策略应模仿一百万年来的进化过程，并且我们必须学习如何利用激素/炎症反应固有的巨大潜力。在这方面，新的课题，如生产线粒体以应对线粒体功能障碍，已成为可能的抗衰老目标。从理论上讲，这种方法通过采用关于营养和身体活动的最有效的，以科学为基础的生活方式，可以调节个人的衰老率和轨迹。在这种情况下，马克·马特森（Mark Mattson）的课程和个人榜样将永久性地启发衰老领域，并寻求健康的衰老和长寿。应对诸如线粒体功能障碍的线粒体产生等新话题正在成为可能的抗衰老目标。从理论上讲，这种方法通过采用关于营养和身体活动的最有效的，以科学为基础的生活方式，可以调节个人的衰老率和轨迹。在这种情况下，马克·马特森（Mark Mattson）的课程和个人榜样将永久性地启发衰老领域，并寻求健康的衰老和长寿。应对诸如线粒体功能障碍的线粒体产生等新话题正在成为可能的抗衰老目标。从理论上讲，这种方法通过采用关于营养和身体活动的最有效的，以科学为基础的生活方式，可以调节个人的衰老率和轨迹。在这种情况下，马克·马特森（Mark Mattson）的课程和个人榜样将永久性地启发衰老领域，并寻求健康的衰老和长寿。