Auraptene and umbelliprenin are among the most abundant naturally occurring prenyloxy umbelliferone derivatives. Both have been mainly isolated from plants belonging to numerous genera of the Rutaceae (in particular auraptene in Citrus spp.) and Apiaceae (in particular umbelliprenin in Ferula spp.) families, comprising different and widely used medicinal plants and in general plants having beneficial effects to human welfare as well as edible fruits and vegetables. Although known for quite a long time (nearly a century for auraptene and 50 years for umbelliprenin), only in the last two decades the two title natural compounds were revealed to possess valuable and promising pharmacological properties as dietary feeding active cancer chemopreventive, anti-bacterial, anti-protozoal, anti-fungal, anti-inflammatory, neuroprotective, and anti-oxidant agents among the activities best detailed in the recent literature. The aim of this comprehensive review is to outline in detail the effects described in the very last years for auraptene and umbelliprenin and what has been reported about the mechanisms of action underlying the observed pharmacological activities of these oxyprenylated secondary metabolites. In view of the herein described data suggestions on how to address the future research about both natural products in the best ways according to Authors will be also provided.

戊二烯和伞形肾上腺素是最丰富的天然戊烯氧基伞形酮衍生物。二者都被来自属于芸香科的许多属植物（特别是在橙皮油素，主要分离柑橘属物种）和伞形科（在特定umbelliprenin阿魏spp。）科，包括不同的和广泛使用的药用植物，以及通常对人类福祉具有有益影响的植物以及可食用的水果和蔬菜。尽管已知了很长的时间（近90年来，金黄色素和umbelliprenin），但仅在最近的二十年中，这两种标题的天然化合物才被发现具有有价值和有希望的药理特性，可作为饮食中的活性癌症化学预防，抗菌剂。活性，抗原生动物，抗真菌，抗炎，神经保护和抗氧化剂等在最近的文献中有最详尽的阐述。这项全面综述的目的是详细概述最近几年对金红素和伞形肾上腺素的影响，以及已报道的有关这些氧炔丙基化次生代谢物的药理活性的作用机理的报道。鉴于本文所述的数据，还将提供根据作者的关于如何以最佳方式应对两种天然产物的未来研究的数据建议。