Embryo implantation is accompanied by a potent inflammatory response, and a gradient of cytokines and chemokines produced by endometrial cells supports the embryo-endometrial interaction. C-reactive protein (CRP) serves as an early marker of inflammation and recent studies have illustrated that controlled ovarian hyperstimulation (COH) could increase its levels. Interestingly, a high chance of pregnancy has been reported in women who had an elevated CRP level on the day of embryo transfer. It seems an elevated systemic inflammation in the in vitro fertilization (IVF) cycle can increase the implantation and pregnancy rates. However, the results regarding the association of CRP with ART outcomes are controversial. Therefore, in this review, we aimed to describe how CRP levels change during a cycle of IVF treatment and which factors can potentially affect this pattern of change. Furthermore, the association of CRP with ART outcomes has been discussed.

胚胎植入伴随着强烈的炎症反应，子宫内膜细胞产生的细胞因子和趋化因子梯度支持胚胎-子宫内膜相互作用。C 反应蛋白 (CRP) 是炎症的早期标志物，最近的研究表明，控制性卵巢过度刺激 (COH) 可以增加其水平。有趣的是，据报道，在胚胎移植当天 CRP 水平升高的女性有很高的怀孕机会。体外受精 (IVF) 周期中全身炎症的升高似乎会增加着床率和妊娠率。然而，关于 CRP 与 ART 结果关联的结果是有争议的。因此，在本次审查中，我们旨在描述在 IVF 治疗周期中 CRP 水平如何变化，以及哪些因素可能会影响这种变化模式。此外，还讨论了 CRP 与 ART 结果的关联。