Cytokines like IL-6, TNF-α, and IL-1β are important mediators of inflammation in many inflammatory diseases, as well as in cellular processes like cell proliferation and cell adhesion. Finding new molecules that decrease cell proliferation, adhesion (inflammatory infiltrate), and pro-inflammatory cytokine release could help in the treatment of many inflammatory diseases. The naturally derived poly(gallic acid) (PGAL), produced enzymatically from gallic acid in aqueous medium, is a non-toxic, thermostable multiradical polyanion that is antioxidant and has potential biomedical uses. Experimental evidence has demonstrated that PGAL reduces pro-inflammatory cytokines, which are the target of some inflammatory diseases. PGAL decreased IL-6, TNF-α, and IL-1β production in human monocytes exposed to PMA without affecting cell viability. Additionally, PGAL reduced cell proliferation by affecting the transition from the S phase to the G2 phase of the cell cycle. Cell adhesion experiments showed that PMA-induced cell adhesion was diminished with the presence of PGAL, particularly at a concentration of 200 μg/mL. These properties of PGAL show a potential use for treating inflammatory diseases, such as psoriasis or arthritis.

IL-6、TNF-α 和 IL-1β 等细胞因子是许多炎症性疾病以及细胞增殖和细胞粘附等细胞过程中炎症的重要介质。寻找减少细胞增殖、粘附（炎症浸润）和促炎细胞因子释放的新分子可能有助于治疗许多炎症性疾病。天然衍生的聚（没食子酸）（PGAL）是由没食子酸在水性介质中酶促产生的，是一种无毒、热稳定的多自由基聚阴离子，具有抗氧化作用，具有潜在的生物医学用途。实验证据表明，PGAL 可减少促炎细胞因子，这是一些炎症性疾病的靶点。PGAL 降低暴露于 PMA 的人单核细胞中 IL-6、TNF-α 和 IL-1β 的产生，而不影响细胞活力。此外，PGAL 通过影响细胞周期从 S 期到 G2 期的转变来减少细胞增殖。细胞粘附实验表明 PMA 诱导的细胞粘附随着 PGAL 的存在而减弱，特别是在 200 μg/mL 的浓度下。PGAL 的这些特性显示出治疗炎症性疾病的潜在用途，例如银屑病或关节炎。