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Engineered Saccharomyces cerevisiae for lignocellulosic valorization: a review and perspectives on bioethanol production
Bioengineered ( IF 4.9 ) Pub Date : 2020-08-15
Joana T. Cunha, Pedro O. Soares, Sara L. Baptista, Carlos E. Costa, Lucília Domingues

ABSTRACT

The biorefinery concept, consisting in using renewable biomass with economical and energy goals, appeared in response to the ongoing exhaustion of fossil reserves. Bioethanol is the most prominent biofuel and has been considered one of the top chemicals to be obtained from biomass. Saccharomyces cerevisiae, the preferred microorganism for ethanol production, has been the target of extensive genetic modifications to improve the production of this alcohol from renewable biomasses. Additionally, S. cerevisiae strains from harsh industrial environments have been exploited due to their robust traits and improved fermentative capacity. Nevertheless, there is still not an optimized strain capable of turning second generation bioprocesses economically viable. Considering this, and aiming to facilitate and guide the future development of effective S. cerevisiae strains, this work reviews genetic engineering strategies envisioning improvements in 2nd generation bioethanol production, with special focus in process-related traits, xylose consumption, and consolidated bioprocessing. Altogether, the genetic toolbox described proves S. cerevisiae to be a key microorganism for the establishment of a bioeconomy, not only for the production of lignocellulosic bioethanol, but also having potential as a cell factory platform for overall valorization of renewable biomasses.



中文翻译:

工程酿酒酵母用于木质纤维素增值:生物乙醇生产的回顾和观点

摘要

生物炼油厂概念的出现,是使用具有经济和能源目标的可再生生物质,是对化石储量不断消耗的回应。生物乙醇是最主要的生物燃料,被认为是从生物质中获得的顶级化学品之一。酿酒酵母,乙醇生产的首选微生物,已成为广泛的遗传修饰的目标,以改善可再生生物质生产这种醇的能力。此外,酿酒酵母由于其强大的特性和提高的发酵能力,已经开发了来自恶劣工业环境的菌株。然而,仍然没有能够使第二代生物过程在经济上可行的优化菌株。考虑到这一点,并旨在促进和指导有效的未来发展酿酒酵母菌株,这项工作审查基因工程战略构想的改进2第二 代生物乙醇的生产,特别侧重于过程相关性状,木糖消耗和综合生物加工。总之,所描述的遗传工具箱可以证明啤酒酵母 成为建立生物经济的关键微生物,不仅用于生产木质纤维素生物乙醇,而且还具有作为可再生生物质整体价值评估的细胞工厂平台的潜力。

更新日期:2020-08-15
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