Aminoglycoside antibiotics treat respiratory infections in cystic fibrosis (CF). An aminoglycoside induced ototoxicity algorithm (AIOA) was implemented to assess ototoxicity among people with CF treated with intravenous and/or inhaled aminoglycosides. Prior to AIOA implementation, 14 of 52 patients (27%) treated with intravenous aminoglycosides had an audiogram. In the 24 months post AIOA implementation, 43 of 44 patients (98%) treated with intravenous aminoglycosides had an audiogram, with 27 (63%) demonstrating abnormalities. Prior to AIOA development, 18 of 70 patients (26%) who received at least two courses of inhaled aminoglycosides had an audiogram. Post AIOA implementation, 33 patients qualified for an audiogram after receiving inhaled aminoglycosides. Of these, 19 (58%) had an audiogram and 10 (53%) had abnormalities. Overall, we identified 46 (61%) people with CF with hearing abnormalities compared to 2.4% in the CF Foundation Patient Registry. This suggests an urgent need for CF programs to implement AIOAs.

中文翻译：

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对囊性纤维化患者实施氨基糖苷类诱导的耳毒性算法

氨基糖苷类抗生素治疗囊性纤维化 (CF) 中的呼吸道感染。实施了氨基糖苷类诱导的耳毒性算法 (AIOA)，以评估接受静脉和/或吸入氨基糖苷类治疗的 CF 患者的耳毒性。在 AIOA 实施之前，接受静脉氨基糖苷类药物治疗的 52 名患者中有 14 名（27%）有听力图。在 AIOA 实施后的 24 个月中，44 名接受静脉氨基糖苷类药物治疗的患者中有 43 名 (98%) 有听力图，其中 27 名 (63%) 显示异常。在 AIOA 开发之前，接受至少两个吸入氨基糖苷类药物治疗的 70 名患者中有 18 名 (26%) 有听力图。AIOA 实施后，33 名患者在接受吸入氨基糖苷类药物后符合听力图检查条件。其中，19 人（58%）有听力图，10 人（53%）有异常。全面的，我们确定了 46 名 (61%) 患有听力异常的 CF 患者，而 CF 基金会患者登记处的这一比例为 2.4%。这表明迫切需要 CF 计划来实施 AIOA。