A novel and practical procedure for the preparation of α-amino secondary amides by the aminocarbonylation of N-Boc-imines using carbamoylsilanes bearing methoxymethyl group as secondary amides source is presented herein. The protocol tolerates N-Boc-imines bearing different groups, including aryl, double bond conjugated aryl, heteroaryl and aliphatic groups. The reactions provide good to excellent yields of the products under mild and catalysts-free conditions. The electronic property and the steric hindrance of substituent on the N-Boc-imines affect the reaction.

中文翻译：

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使用氨基甲酰基硅烷作为酰胺源，通过N-Boc-亚胺的直接氨基羰基化反应，高效合成α-氨基仲酰胺

本文提出了一种新颖且实用的方法，该方法通过使用带有甲氧基甲基的氨基甲酰基硅烷作为仲酰胺源，通过N-Boc-亚胺的氨基羰基化来制备α-氨基仲酰胺。该方案容许带有不同基团的N-Boc-亚胺，包括芳基，双键共轭芳基，杂芳基和脂族基团。在温和且无催化剂的条件下，反应可提供良好的产品收率。N-Boc-亚胺上取代基的电子性质和位阻会影响反应。