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Cytotoxic sesquiterpene lactones from Campuloclinium macrocephalum (=Eupatorium macrocephalum)
Phytochemistry ( IF 3.8 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.phytochem.2020.112469
Márcia R Pereira Cabral 1 , Mariana Cecchetto 2 , João M Batista 3 , Andrea N L Batista 4 , Mary Ann Foglio 2 , Ana Lúcia Tasca Gois Ruiz 2 , Marta R Barrotto do Carmo 5 , Willian Ferreira da Costa 1 , Débora C Baldoqui 1 , Maria H Sarragiotto 1
Affiliation  

Three undescribed germacranolide sesquiterpene lactones, named macrocephalides A-C, along with known steroids, triterpenes and flavonoids were isolated from the aerial parts of Campuloclinium macrocephalum. The structures of the undescribed compounds were elucidated with basis on their 1D and 2D-NMR, and HR-ESI-MS data. Their absolute configurations were assigned by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Additionally, macrocephalides A-C were evaluated for their in vitro cytotoxic activities against nine human cancer cell lines. Macrocephalides A and B exhibited moderate to potent cytotoxic activity, inhibiting 50% of cell growth (GI50) at concentrations ranging from 0.576 to 6.37 μM.

中文翻译:

来自 Campuloclinium macrocephalum (=Eupatorium macrocephalum) 的细胞毒性倍半萜内酯

从 Campuloclinium macrocephalum 的地上部分分离出三种未描述的 Germacranolide 倍半萜内酯,命名为 macrocephalides AC,以及已知的类固醇、三萜和类黄酮。未描述的化合物的结构根据它们的 1D 和 2D-​​NMR 以及 HR-ESI-MS 数据进行阐明。它们的绝对构型是通过比较实验和计算的电子圆二色性 (ECD) 光谱来分配的。此外,还评估了巨头内酯 AC 对 9 种人类癌细胞系的体外细胞毒活性。Macrocephalides A 和 B 表现出中等至强效的细胞毒活性,在 0.576 至 6.37 μM 的浓度范围内抑制 50% 的细胞生长 (GI50)。
更新日期:2020-11-01
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