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Evidence that haloperidol impairs learning and motivation scores in a probabilistic task by reducing the reward expectation.
Behavioural Brain Research ( IF 2.7 ) Pub Date : 2020-08-15 , DOI: 10.1016/j.bbr.2020.112858
Bernadete Negrelli 1 , José Augusto Pochapski 1 , Cyrus Antonio Villas-Boas 1 , Letícia Ferreira Jessen 1 , Mayra Aline Lopes Teixeira 1 , Claudio Da Cunha 1
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Activation of midbrain dopamine neurons in response to positive prediction errors and reward predictive cues is proposed to “energize” reward seeking behaviors and approach responses to places where the reward is expected. In the present study, we tested the effect of the D2-dopamine receptor antagonist haloperidol on response latencies to enter two arms of a Y-maze with different reward probabilities. Adult male Wistar rats were trained to explore the Y-maze with sucrose pellets placed 30% of times at the end of one arm and 70% of times at the opposite arm. Therefore, the reward expectation was different among arms, and was updated in the trials when the reward was omitted. After training, rats received 0.05, 0.10, 0.15 mg/kg haloperidol, or saline 30 min before the test session. In the last, but not in the first trials, haloperidol caused a dose-dependent increase in arm choice latency and response latency. Saline, but not haloperidol, treated rats presented significantly longer response latencies for the 30% compared to the 70% reward probability arm. Haloperidol also caused a dose-dependent decrease in the number of entries in the 70% reward probability arm, increased the number of non-responses, and caused a dose-dependent increase in the number of re-entries in the 30% reward probability arm after non-rewarded trials. Control experiments suggested that haloperidol did not cause motor impairment or satiation, but rather impaired learning and motivation scores by reducing the reward expectation.



中文翻译:

氟哌啶醇通过降低奖励期望来损害概率任务中的学习和动机分数的证据。

响应积极的预测错误和奖励预测线索激活中脑多巴胺神经元被提议“激励”寻求奖励的行为并接近对预期奖励的地方的反应。在本研究中,我们测试了 D2-多巴胺受体拮抗剂氟哌啶醇对进入具有不同奖励概率的 Y 迷宫两个臂的反应延迟的影响。训练成年雄性 Wistar 大鼠探索 Y 迷宫,其中蔗糖颗粒放置在一只手臂的末端,30% 的次数和 70% 次放置在另一只手臂。因此,各组之间的奖励期望不同,并且在忽略奖励时在试验中更新。训练后,大鼠在测试前 30 分钟接受 0.05、0.10、0.15 mg/kg 氟哌啶醇或生理盐水。在最后的试炼中,但不是在最初的试炼中,氟哌啶醇导致手臂选择潜伏期和反应潜伏期的剂量依赖性增加。与 70% 奖励概率臂相比,盐水(但不是氟哌啶醇)处理的大鼠表现出显着更长的 30% 响应延迟。氟哌啶醇还导致 70% 奖励概率组的进入次数呈剂量依赖性减少,不响应数量增加,并导致 30% 奖励概率组重新进入的次数呈剂量依赖性增加在无奖励的试验之后。对照实验表明氟哌啶醇不会导致运动障碍或饱腹感,而是通过降低奖励期望来损害学习和动机分数。与 70% 奖励概率组相比,接受治疗的大鼠在 30% 组中表现出明显更长的反应延迟。氟哌啶醇还导致 70% 奖励概率组的进入次数呈剂量依赖性减少,不响应数量增加,并导致 30% 奖励概率组重新进入的次数呈剂量依赖性增加在无奖励的试验之后。对照实验表明氟哌啶醇不会导致运动障碍或饱腹感,而是通过降低奖励期望来损害学习和动机分数。与 70% 奖励概率组相比,接受治疗的大鼠在 30% 组中表现出明显更长的反应延迟。氟哌啶醇还导致 70% 奖励概率组的进入次数呈剂量依赖性减少,不响应数量增加,并导致 30% 奖励概率组重新进入的次数呈剂量依赖性增加在无奖励的试验之后。对照实验表明氟哌啶醇不会导致运动障碍或饱腹感,而是通过降低奖励期望来损害学习和动机分数。并导致在非奖励试验后重新进入 30% 奖励概率臂的次数呈剂量依赖性增加。对照实验表明氟哌啶醇不会导致运动障碍或饱腹感,而是通过降低奖励期望来损害学习和动机分数。并导致在非奖励试验后重新进入 30% 奖励概率臂的次数呈剂量依赖性增加。对照实验表明氟哌啶醇不会导致运动障碍或饱腹感,而是通过降低奖励期望来损害学习和动机分数。

更新日期:2020-08-28
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