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Bidirectional interaction between intestinal microbiome and cancer: opportunities for therapeutic interventions.
Biomarker Research ( IF 11.1 ) Pub Date : 2020-08-12 , DOI: 10.1186/s40364-020-00211-6
Dibyendu Dutta 1, 2 , Seah H Lim 1, 2
Affiliation  

Gut microbiota composition influences the balance between human health and disease. Increasing evidence suggests the involvement of microbial factors in regulating cancer development, progression, and therapeutic response. Distinct microbial species have been implicated in modulating gut environment and architecture that affects cancer therapy outcomes. While some microbial species offer enhanced cancer therapy response, others diminish cancer treatment efficacy. In addition, use of antibiotics, often to minimize infection risks in cancer, causes intestinal dysbiosis and proves detrimental. In this review we discuss the role of gut microbiota in cancer development and therapy. We also provide insights into future strategies to manipulate the microbiome and gut epithelial barrier to augment therapeutic responses while minimizing toxicity or infection risks.

中文翻译:

肠道微生物组与癌症之间的双向相互作用:治疗干预的机会。

肠道菌群组成影响人类健康与疾病之间的平衡。越来越多的证据表明微生物因子参与调节癌症的发展,进程和治疗反应。不同的微生物物种已经牵涉到调节肠道环境和结构,从而影响癌症治疗的结果。虽然某些微生物物种可增强癌症治疗反应,但其他微生物却降低了癌症治疗功效。另外,使用抗生素通常可以最大程度地降低癌症的感染风险,引起肠道营养不良并证明是有害的。在这篇综述中,我们讨论了肠道菌群在癌症发展和治疗中的作用。
更新日期:2020-08-14
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